Results 71 to 80 of about 204,216 (218)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Global Qibla Direction Using Stellar Transit at Kaaba Latitude

Al-Hilal
The global rashd al-qiblah is currently considered the most accurate and easily applicable method for measuring the qibla direction, as it utilizes the sun’s shadow during its transit above the Kaaba.
Fathurrahman Fathurrahman, Fika Afhamul Fuscha   +1 more
doaj   +1 more source

Belarusian-Lithuanian Relations: How Politics Beats the Economy [PDF]

Современная Европа
The article analyses the dynamics of Belarusian-Lithuanian relations in the post-Soviet period. The historical, cultural and political-economic aspects of the relationship between the two countries are considered. It is noted that Lithuania is the second
Vsevolod V. Shimov
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Winnipeg’s community safety team: Two years of meaningful impact

Journal of Community Safety and Well-Being
Winnipeg’s community safety team was established in 2023 with a mission to improve safety within the city’s bus system and public spaces. It added a tier to the network of emergency services and community-based organizations that became overwhelmed with ...
Gehdian Wardrope, Bob Chrismas
doaj   +1 more source

Multimodal approach to the international transit transport

Transport, 2003
In the article not only the problems of multi-modal and inter-modal conveyances in Lithuania and the concept of transit and the transit system stimulating factors are analysed, but also the modelling of transit transport and the flows of the loads are ...
Darius Bazaras, Ramūnas Palšaitis
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT

Frontiers in Neuroscience, 2013
Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit peristalsis and GI-transit in ...
Tiong Cheng Sia, Malcolm eWhiting, Melinda eKyloh, Sarah eNicholas, Simon J Brookes, John eOliver, Phil eDinning, David A Wattchow, Nick J Spencer   +8 more
doaj   +1 more source