Results 151 to 160 of about 133,301 (317)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Public Transit in America: Analysis of Access Using the 2001 National Household Travel Survey [PDF]

, 2007
Understanding transit ridership has become a critical research interest and policy goal. This paper presents the results of an analysis of the National Household Travel Survey (NHTS) data specifically focusing on the appended variables that measure ...
Polzin, Steven E, Maggio, Edward, Chu, Xuehao   +2 more
core  

Empirical Study on the Relationship between Urban Development around Rail Transit Stations and Station Passenger Flow in Japan

Chengshi guidao jiaotong yanjiu
Objective The development of areas around urban rail transit station in China generally lags behind urban development and construction, and the coordination relationship between stations and their surrounding urban development is not optimistic.
Feng LI, Yongchao ZHANG, Yiting JIANG
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The role of gut microbiota in chronic intestinal pseudo-obstruction: exploring fecal microbiota transplantation as a treatment option

Gut Microbes
Chronic intestinal pseudo-obstruction (CIPO) is characterized by bowel dilation and obstructive symptoms without any structural blockage. Although the microbiota is known to affect gastrointestinal function, its role in CIPO is poorly understood.
Giada De Palma, Anna Costanzini, Vidhyalakshmi Mohan, Sacha Sidani, Zarwa Saqib, Marc Pigrau, Jun Lu, Natalia Causada Calo, Ines Pinto-Sanchez, Elena F. Verdu, Margaret Marcon, Giovanni Barbara, Vincenzo Stanghellini, Roberto De Giorgio, Stephen M. Collins, Premysl Bercik   +15 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Revisiting transit accessibility: effect of stochasticity, real-time information, congestion, and network structure

Journal of Engineering and Applied Science
A novel transit accessibility measure is proposed following a utility framework to account for the stochasticity in transit services, the effect of real-time information, traffic congestion, and structural features of the transit network, which are ...
Sethu Vinayagam Udhayasekar, Karthik K. Srinivasan, Bhargava Rama Chilukuri   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source