Results 101 to 110 of about 9,228,850 (295)

The Role of Transit Amenities and Vehicle Characteristics in Building Transit Ridership: Amenities for Transit Handbook and The Transit Design Game Workbook

open access: yes, 1999
This report consists of a Handbook and a Workbook. The Handbook identifies and describes passenger amenities and transit vehicle characteristics that attract ridership and explores how amenities may affect ridership.
Transportation Research Board   +1 more
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

NJ Transit Minutes

open access: yes, 2020
Downloaded from: https://www.njtransit.com/board-meeting-minutes Minutes, Covid survey presentation and Transit grid presentation are in separate ...
NJ Transit
core  

Potential Uses of Transit Smart Card Registration and Transaction Data to Improve Transit Planning

open access: yes, 2006
New automated fare collection systems being implemented on urban rail and bus transit systems offer the potential of tapping a rich source of customer usage data to improve transit planning.
Mariko Utsunomiya   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Exploring the mechanism of Tongyou Decoction on slow transit constipation rats via ICC/ANO1/PDGFRα+-SK3 pathway

open access: yesJournal of Radiation Research and Applied Sciences
Background and aim: Traditional Chinese medicine has received attention as a potential method for treating STC. This investigation aimed to identify the target for therapy and the mechanism of Tongyou Decoction in STC by employing a rat model induced ...
Xiaopin Chen   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy