Characterizing Habitable Exo-Moons
, 2010 We discuss the possibility of screening the atmosphere of exomoons for habitability. We concentrate on Earth-like satellites of extrasolar giant planets (EGP) which orbit in the Habitable Zone of their host stars. The detectability of exomoons for EGP in
Barnes +21 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Compressed television transmission: A market survey [PDF]
NASA's compressed television transmission technology is described, and its potential market is considered; a market that encompasses teleconferencing, remote medical diagnosis, patient monitoring, transit station surveillance, as well as traffic ...
Cagan, L. Q., Lizak, R. M.
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INTERNATIONAL TRANSIT VIA THE NORTHERN SEA ROUTE: THREATS, OPPORTUNITIES, AND FUTURE PROSPECTS
Север и рынок: формирование экономического порядкаThe Northern Sea Route (NSR) is a historically significant transport corridor in Russia and a crucial component of the country’s national and economic security.
Anna B. Nikolaeva
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The effects of milk matrices on the transit and digestion of secretory immunoglobulin A in the gut : a thesis presented in partial fulfilment of requirements for the degree of Masters of Science in Animal Science at Massey University, Palmerston North, New Zealand and AgResearch, Ruakura, Hamilton, New Zealand [PDF]
, 2017 Figures 1-8 have been removed for copyright reasons, but may be accessed from their sources listed in the bibliographyBovine secretory immunoglobulin A (BSIgA) has the potential to provide protective effects to the gastrointestinal tract (GIT) when ...
O'Connor, Chrystal Te Ohorere
core
Fano resonance in the nonadiabatic pumped shot noise of a time-dependent potential well
, 2014 We use the Floquet scattering theory to study the correlation properties of the nonadiabatic pumped dc current and heat flow through a time-dependent potential well.
Dai, Jiao-Hua, Zhu, Rui
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Gateway Lunar Habitat Modules as the Basis for a Modular Mars Transit Habitat [PDF]
This paper provides a summary of the results from a recent concept study of various configurations for a Mars Transit Habitat. The designs considered are composed of modules based on published contractor concepts proposed for the lunar Gateway through ...
Schnell, Andrew, Smitherman, David
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