Results 81 to 90 of about 131,449 (311)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Analysis of spatial features and determination of metropolitan area boundaries in the Guanzhong region affected by intercity rail transit

Discover Applied Sciences
This study explores how intercity rail transit reshapes spatial structures, which underpins the optimization of regional resource allocation. Taking 54 county-level units in the Guanzhong region as research subjects, we constructed a dual-model ...
Chunjie Cai, Pei Zhang
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Earth's Atmospheric Electricity Parameter Response During Venus Transit

Terrestrial, Atmospheric and Oceanic Sciences, 2015
Venus transited across the Sun on 06 June 2012, introducing significant contribution to the tidal characteristics of the solar atmosphere. _ atmosphere was perturbed due to an anomalous Coronal Mass Ejection (CME) and γ-radiationγ-radiation influenced by
Syam Sundar De, Suman Paul, Sudarsan Barui, Dilip Kumar Haldar, and Gautam Guha   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Technology Research on Rail Potential Limit of Urban Rail Transit

机车电传动, 2018
The OVPD device is an important component of the protective equipment in the power supply system of urban rail transit. Basic principle of rail potential limiting protection for urban rail transit was analyzed, and a new type of rail potential limiter ...
CHEN Chaolu, YANG Yang, XIE Peijin, HU Ping, CHEN Hui   +4 more
doaj  

Evaluating transit-oriented development (TOD) in Khartoum: A spatial analysis of bus terminals

Journal of Urban Management
This study evaluates the potential for Transit-Oriented Development (TOD) in Khartoum, Sudan, a rapidly urbanizing city facing critical transportation challenges.
Mohammed M. Ali, Ghada M. Alssadah, Yang Yu, Muna M. Altahir, Mohamed A. Damos, Rui Zhou, Hamid Abdrhman   +6 more
doaj   +1 more source

Development of Transit Potential of the Northern Sea Route

Контуры глобальных трансформаций: политика, экономика, право, 2021
The Article defines the sectoral structure of the Northern Sea transport corridor, the set of the transport tasks provided by them - the international transit, import and export operations, and considers internal transportation.
M. N. Grigoryev
doaj