Results 131 to 140 of about 76,246 (270)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

TrES-1 b: A Case Study in Detecting Secular Evolution of Exoplanet Orbits

The Astronomical Journal
We present a comprehensive analysis of transit, eclipse, and radial velocity data of the hot Jupiter TrES-1 b and confirm evidence of orbital variations on secular timescales.
Simone R. Hagey, Billy Edwards, Angelos Tsiaras, Aaron C. Boley, Anastasia Kokori, Norio Narita, Pedro V. Sada, Filip Walter, Robert T. Zellem, Napaporn A-thano, Kevin B. Alton, Miguel Ángel Álava Amat, Paul Benni, Emmanuel Besson, Patrick Brandebourg, Marc Bretton, Mauro Caló, Martin Valentine Crow, Jean-Christophe Dalouzy, Marc Deldem, Tõnis Eenmäe, Stephane Ferratfiat, Pere Guerra, Gary Vander Haagen, Ken Hose, Adrian Jones, Yves Jongen, Didier Laloum, Stefano Lora, Alessandro Marchini, Jacques Michelet, Matej Mihelčič, Johannes Mieglitz, Eric Miny, David Molina, Mario Morales Aimar, Raphael Nicollerat, Ivo Peretto, Manfred Raetz, François Regembal, Robert Roth, Lionel Rousselot, Mark Salisbury, Darryl Sergison, Anaël Wünsche, Jaroslav Trnka   +45 more
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

The Exoplanet Edge: Planets Do Not Induce Observable Transit Timing Variations with a Dominant Transit Timing Variation Period Faster than Half Their Orbital Period

The Astrophysical Journal Letters
Transit timing variations (TTVs) are observed for exoplanets at a range of amplitudes and periods, yielding an ostensibly degenerate forest of possible explanations.
Daniel A. Yahalomi, David Kipping, Eric Agol, David Nesvorný   +3 more
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Creating Pileups of Eccentric Planet Pairs Wide of Mean Motion Resonances through Divergent Migration

The Astrophysical Journal
Observed pileups of planets with period ratios ≈1% wide of strong mean motion resonances (MMRs) pose an important puzzle. Early models showed that they can be created through sustained eccentricity damping, driving a slow separation of the orbits, but ...
Jingyun Lin, Ivan Dudiak, Samuel Hadden, Daniel Tamayo   +3 more
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source