Results 121 to 130 of about 13,276,104 (255)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
TOI-2015 b: A Warm Neptune with Transit Timing Variations Orbiting an Active Mid-type M Dwarf
The Astronomical JournalWe report the discovery of a close-in ( P _orb = 3.349 days) warm Neptune with clear transit timing variations (TTVs) orbiting the nearby ( d = 47.3 pc) active M4 star, TOI-2015.
Sinclaire E. Jones +31 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Assessing the Costs for Hybrid versus Regular Transit Buses, October 2012 [PDF]
, 2012 This technical brief summarizes information about the costs and benefits that have been attributed to use of hybrid transit buses as found in the literature.
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Maintenance Technician Staffing Levels for Modern Public Transit Fleets
, 2016 TRB’s Transit Cooperative Research Program (TCRP) Report 184: Maintenance Technician Staffing Levels for Modern Public Transit Fleets identifies existing tools and practices used to determine optimum maintenance technician staffing levels.
Transportation Learning Center +3 more
core +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Transit Timing of the White Dwarf-cold Jupiter System WD 1856+534
The Astronomical JournalWe present new transit-timing measurements for the white dwarf-cold Jupiter system WD 1856+534, extending the baseline of observations from 311 epochs to 1498 epochs.
Eli A. Gendreau-Distler +19 more
doaj +1 more source