Results 101 to 110 of about 6,653 (227)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The TESS-Keck Survey. XVII. Precise Mass Measurements in a Young, High-multiplicity Transiting Planet System Using Radial Velocities and Transit Timing Variations

The Astronomical Journal
We present a radial velocity (RV) analysis of TOI-1136, a bright Transiting Exoplanet Survey Satellite (TESS) system with six confirmed transiting planets, and a seventh single-transiting planet candidate.
Corey Beard, Paul Robertson, Fei Dai, Rae Holcomb, Jack Lubin, Joseph M. Akana Murphy, Natalie M. Batalha, Sarah Blunt, Ian Crossfield, Courtney Dressing, Benjamin Fulton, Andrew W. Howard, Dan Huber, Howard Isaacson, Stephen R. Kane, Grzegorz Nowak, Erik A Petigura, Arpita Roy, Ryan A. Rubenzahl, Lauren M. Weiss, Rafael Barrena, Aida Behmard, Casey L. Brinkman, Ilaria Carleo, Ashley Chontos, Paul A. Dalba, Tara Fetherolf, Steven Giacalone, Michelle L. Hill, Kiyoe Kawauchi, Judith Korth, Rafael Luque, Mason G. MacDougall, Andrew W. Mayo, Teo Močnik, Giuseppe Morello, Felipe Murgas, Jaume Orell-Miquel, Enric Palle, Alex S. Polanski, Malena Rice, Nicholas Scarsdale, Dakotah Tyler, Judah Van Zandt   +43 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mapping the Orbital Landscape of Perturbing Planet Solutions for Single-planet Systems with TTVs

The Astrophysical Journal
There are now thousands of single-planet systems observed to exhibit transit timing variations (TTVs), yet we largely lack any interpretation of the implied masses responsible for these perturbations.
Daniel A. Yahalomi, David Kipping
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A Fourth Planet in the Kepler-51 System Revealed by Transit Timing Variations

The Astronomical Journal
Kepler-51 is a ≲1 Gyr old Sun-like star hosting three transiting planets with radii ≈6–9 R _⊕ and orbital periods ≈45–130 days. Transit timing variations (TTVs) measured with past Kepler and Hubble Space Telescope (HST) observations have been ...
Kento Masuda, Jessica E. Libby-Roberts, John H. Livingston, Kevin B. Stevenson, Peter Gao, Shreyas Vissapragada, Guangwei Fu, Te Han, Michael Greklek-McKeon, Suvrath Mahadevan, Eric Agol, Aaron Bello-Arufe, Zachory Berta-Thompson, Caleb I. Cañas, Yayaati Chachan, Leslie Hebb, Renyu Hu, Yui Kawashima, Heather A. Knutson, Caroline V. Morley, Catriona A. Murray, Kazumasa Ohno, Armen Tokadjian, Xi Zhang, Luis Welbanks, Matthew C. Nixon, Richard Freedman, Norio Narita, Akihiko Fukui, Jerome P. de Leon, Mayuko Mori, Enric Palle, Felipe Murgas, Hannu Parviainen, Emma Esparza-Borges, Daniel Jontof-Hutter, Karen A. Collins, Paul Benni, Khalid Barkaoui, Francisco J. Pozuelos, Michaël Gillon, Emmanuël Jehin, Zouhair Benkhaldoun, Suzanne Hawley, Andrea S. J. Lin, Guđmundur Stefánsson, Allyson Bieryla, Mesut Yilmaz, Hakan Volkan Senavci, Eric Girardin, Giuseppe Marino, Gavin Wang   +51 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Giant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. IV. Long-term Doppler Spectroscopy for 11 Stars Thought to Host Cool Giant Exoplanets

The Astrophysical Journal Supplement Series
Discovering and characterizing exoplanets at the outer edge of the transit method’s sensitivity has proven challenging owing to geometric biases and the practical difficulties associated with acquiring long observational baselines.
Paul A. Dalba, Stephen R. Kane, Howard Isaacson, Benjamin Fulton, Andrew W. Howard, Edward W. Schwieterman, Daniel P. Thorngren, Jonathan Fortney, Noah Vowell, Corey Beard, Sarah Blunt, Casey L. Brinkman, Ashley Chontos, Fei Dai, Steven Giacalone, Michelle L. Hill, Molly Kosiarek, Jack Lubin, Andrew W. Mayo, Teo Močnik, Joseph M. Akana Murphy, Erik A. Petigura, Malena Rice, Ryan A. Rubenzahl, Judah Van Zandt, Lauren M. Weiss, Diana Dragomir, David Kipping, Matthew J. Payne, Arpita Roy, Alex Teachey, Steven Villanueva Jr.   +31 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source