Results 91 to 100 of about 6,579 (217)

A Fourth Planet in the Kepler-51 System Revealed by Transit Timing Variations

The Astronomical Journal
Kepler-51 is a ≲1 Gyr old Sun-like star hosting three transiting planets with radii ≈6–9 R _⊕ and orbital periods ≈45–130 days. Transit timing variations (TTVs) measured with past Kepler and Hubble Space Telescope (HST) observations have been ...
Kento Masuda, Jessica E. Libby-Roberts, John H. Livingston, Kevin B. Stevenson, Peter Gao, Shreyas Vissapragada, Guangwei Fu, Te Han, Michael Greklek-McKeon, Suvrath Mahadevan, Eric Agol, Aaron Bello-Arufe, Zachory Berta-Thompson, Caleb I. Cañas, Yayaati Chachan, Leslie Hebb, Renyu Hu, Yui Kawashima, Heather A. Knutson, Caroline V. Morley, Catriona A. Murray, Kazumasa Ohno, Armen Tokadjian, Xi Zhang, Luis Welbanks, Matthew C. Nixon, Richard Freedman, Norio Narita, Akihiko Fukui, Jerome P. de Leon, Mayuko Mori, Enric Palle, Felipe Murgas, Hannu Parviainen, Emma Esparza-Borges, Daniel Jontof-Hutter, Karen A. Collins, Paul Benni, Khalid Barkaoui, Francisco J. Pozuelos, Michaël Gillon, Emmanuël Jehin, Zouhair Benkhaldoun, Suzanne Hawley, Andrea S. J. Lin, Guđmundur Stefánsson, Allyson Bieryla, Mesut Yilmaz, Hakan Volkan Senavci, Eric Girardin, Giuseppe Marino, Gavin Wang   +51 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Giant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. IV. Long-term Doppler Spectroscopy for 11 Stars Thought to Host Cool Giant Exoplanets

The Astrophysical Journal Supplement Series
Discovering and characterizing exoplanets at the outer edge of the transit method’s sensitivity has proven challenging owing to geometric biases and the practical difficulties associated with acquiring long observational baselines.
Paul A. Dalba, Stephen R. Kane, Howard Isaacson, Benjamin Fulton, Andrew W. Howard, Edward W. Schwieterman, Daniel P. Thorngren, Jonathan Fortney, Noah Vowell, Corey Beard, Sarah Blunt, Casey L. Brinkman, Ashley Chontos, Fei Dai, Steven Giacalone, Michelle L. Hill, Molly Kosiarek, Jack Lubin, Andrew W. Mayo, Teo Močnik, Joseph M. Akana Murphy, Erik A. Petigura, Malena Rice, Ryan A. Rubenzahl, Judah Van Zandt, Lauren M. Weiss, Diana Dragomir, David Kipping, Matthew J. Payne, Arpita Roy, Alex Teachey, Steven Villanueva Jr.   +31 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Investigating the Atmospheric Mass Loss of the Kepler-105 Planets Straddling the Radius Gap

The Astronomical Journal
An intriguing pattern among exoplanets is the lack of detected planets between approximately 1.5 R _⊕ and 2.0 R _⊕ . One proposed explanation for this “radius gap” is the photoevaporation of planetary atmospheres, a theory that can be tested by studying ...
Aaron Householder, Lauren M. Weiss, James E. Owen, Howard Isaacson, Andrew W. Howard, Daniel Fabrycky, Leslie A. Rogers, Hilke E. Schlichting, Benjamin J. Fulton, Erik A. Petigura, Steven Giacalone, Joseph M. Akana Murphy, Corey Beard, Ashley Chontos, Fei Dai, Judah Van Zandt, Jack Lubin, Malena Rice, Alex S. Polanski, Paul Dalba, Sarah Blunt, Emma V. Turtelboom, Ryan Rubenzahl, Casey Brinkman   +23 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Tidally Heated Sub-Neptunes, Refined Planetary Compositions, and Confirmation of a Third Planet in the TOI-1266 System

The Astronomical Journal
TOI-1266 is a benchmark system of two temperate (
Michael Greklek-McKeon, Shreyas Vissapragada, Heather A. Knutson, Akihiko Fukui, Morgan Saidel, Jonathan Gomez Barrientos, W. Garrett Levine, Aida Behmard, Konstantin Batygin, Yayaati Chachan, Gautam Vasisht, Renyu Hu, Ryan Cloutier, David Latham, Mercedes López-Morales, Andrew Vanderburg, Carolyn Heffner, Paul Nied, Jennifer Milburn, Isaac Wilson, Diana Roderick, Kathleen Koviak, Tom Barlow, John F. Stone, Rocio Kiman, Judith Korth, Jerome P. de Leon, Izuru Fukuda, Yuya Hayashi, Masahiro Ikoma, Kai Ikuta, Keisuke Isogai, Yugo Kawai, Kiyoe Kawauchi, Nobuhiko Kusakabe, John H. Livingston, Mayuko Mori, Norio Narita, Motohide Tamura, Noriharu Watanabe, Gareb Fernández-Rodríguez   +40 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A Compact Multiplanet System of Three Transiting Giant Planets around TIC 118798035

The Astrophysical Journal Letters
We report the discovery and characterization of three transiting giant planets in the TIC 118798035 system. The three planets were identified as transiting candidates from data of the TESS mission and confirmed with ground-based photometric transit ...
Rafael Brahm, Trifon Trifonov, Andrés Jordán, Thomas Henning, Néstor Espinoza, Felipe I. Rojas, Marcelo Tala Pinto, Matías I. Jones, Daniel Thorngren, Lorena Acuña, Jan Eberhardt, Yared Reinarz, Helem Salinas, Michaela Vítková, Juan I. Espinoza-Retamal, Gaspar Bakos, Attila Bódi, Gavin Boyle, Zoltán Csubry, Joel Hartman, Anthony Keyes, Vincent Suc, Geert Jan Talens   +22 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source