Results 71 to 80 of about 13,276,015 (255)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Accounting for Transit Timing Detectability: Biases in Planetary Radius and Orbital Period
The Astronomical JournalTransit Timing Variations (TTVs) are deviations from the time an observer would expect to see an exoplanet transit its host star. In multiplanetary systems, significant TTVs may indicate the presence of another body in the system gravitationally ...
Skylar D’Angiolillo +2 more
doaj +1 more source
, 2006 Between 1990 and 2000, transit patronage increased by around 7% in the United States, but there has been wide variation around this mean. Most research attributes variation in ridership change to a combination of socioeconomic and land use factors, which
Brown, Jeffrey R, Thompson, Gregory Lee
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Inferring Exoplanet Parameters from Transit Timing Variations Using LSTM Networks
The Planetary Science JournalTransit timing variation (TTV) analysis provides a valuable complement to traditional transit and radial-velocity techniques, particularly in compact, near-resonant planetary systems where dynamical interactions amplify timing signals and refine mass and
Muhammad Isnaenda Ikhsan +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A Decade of Transit-timing Measurements Confirm Resonance in the K2-19 System
The Astronomical JournalK2-19 is a star, slightly smaller than the Sun, that hosts three transiting planets. Two of these, K2-19 b and c, are between the size of Neptune and Saturn and have orbital periods near a 3:2 commensurability, and exhibit strong transit-timing ...
Paige M. Entrican +4 more
doaj +1 more source
Cybersecurity Resilience Assessment Tool to Enhance Public Confidence in Transit [PDF]
I n 2021, the Federal Transit Administration (FTA) awarded the Rock Island County Metropolitan Mass Transit District (MetroLINK) a grant to develop a cybersecurity assessment tool to assess its cyber posture as part of FTA\u2019s Public Transportation ...
Thomas, Brandon +6 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source