Results 81 to 90 of about 6,579 (217)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

In Search of Decay: An Analysis of Transit Times of Hot Jupiters in Main-sequence and Post-main-sequence Systems

The Astrophysical Journal
Tidal interactions are one of the primary drivers of orbital evolution for massive planets with short orbital periods. Tidal dissipation within host stars can cause the orbits of such planets to decay.
Noah Sodickson, Samuel Grunblatt
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Orbital Decay of the Ultra-hot Jupiter TOI-2109b: Tidal Constraints and Transit-timing Analysis

The Astrophysical Journal
TOI-2109b is the ultra-hot Jupiter with the shortest orbital period (∼16 hr) yet discovered. At this close distance, strong tidal interactions can produce a significant exchange of angular momentum with the star.
Jaime A. Alvarado-Montes, Mario Sucerquia, Jorge I. Zuluaga, Christian Schwab   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The TESS-Keck Survey. XVII. Precise Mass Measurements in a Young, High-multiplicity Transiting Planet System Using Radial Velocities and Transit Timing Variations

The Astronomical Journal
We present a radial velocity (RV) analysis of TOI-1136, a bright Transiting Exoplanet Survey Satellite (TESS) system with six confirmed transiting planets, and a seventh single-transiting planet candidate.
Corey Beard, Paul Robertson, Fei Dai, Rae Holcomb, Jack Lubin, Joseph M. Akana Murphy, Natalie M. Batalha, Sarah Blunt, Ian Crossfield, Courtney Dressing, Benjamin Fulton, Andrew W. Howard, Dan Huber, Howard Isaacson, Stephen R. Kane, Grzegorz Nowak, Erik A Petigura, Arpita Roy, Ryan A. Rubenzahl, Lauren M. Weiss, Rafael Barrena, Aida Behmard, Casey L. Brinkman, Ilaria Carleo, Ashley Chontos, Paul A. Dalba, Tara Fetherolf, Steven Giacalone, Michelle L. Hill, Kiyoe Kawauchi, Judith Korth, Rafael Luque, Mason G. MacDougall, Andrew W. Mayo, Teo Močnik, Giuseppe Morello, Felipe Murgas, Jaume Orell-Miquel, Enric Palle, Alex S. Polanski, Malena Rice, Nicholas Scarsdale, Dakotah Tyler, Judah Van Zandt   +43 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Mapping the Orbital Landscape of Perturbing Planet Solutions for Single-planet Systems with TTVs

The Astrophysical Journal
There are now thousands of single-planet systems observed to exhibit transit timing variations (TTVs), yet we largely lack any interpretation of the implied masses responsible for these perturbations.
Daniel A. Yahalomi, David Kipping
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source