Results 51 to 60 of about 13,276,015 (255)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

TOI-4504: Exceptionally Large Transit Timing Variations Induced by Two Resonant Warm Gas Giants in a Three-planet System

The Astrophysical Journal Letters
We present a joint analysis of transit timing variations (TTVs) and Doppler data for the transiting exoplanet system TOI-4504. TOI-4504 c is a warm Jupiter-mass planet that exhibits the largest known TTVs, with a peak-to-node amplitude of ∼2 days, the ...
Michaela Vítková, Rafael Brahm, Trifon Trifonov, Petr Kabáth, Andrés Jordán, Thomas Henning, Melissa J. Hobson, Jan Eberhardt, Marcelo Tala Pinto, Felipe I. Rojas, Nestor Espinoza, Martin Schlecker, Matías I. Jones, Maximiliano Moyano, Susana Eyheramendy, Carl Ziegler, Jack J. Lissauer, Andrew Vanderburg, Karen A. Collins, Bill Wohler, David Watanabe, George R. Ricker, Roland Vanderspek, Sara Seager, Joshua N. Winn, Jon M. Jenkins, Marek Skarka   +26 more
doaj   +1 more source

CONSIDERING BUILD-LATER FOR MAJOR TRANSIT INVESTMENTS

, 1998
This paper uses a theoretical model of benefit-cost analysis to consider the timing of major transit investments. The model takes into account the net benefits of a project, the variation of net benefits with project age and investment timing, capital ...
Polzin, Steven E, Chu, Xuehao
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Constraining the Presence of Companion Planets in Hot Jupiter Planetary Systems Using Transit-timing Variation Observations from TESS

The Astrophysical Journal Supplement Series
The presence of another planetary companion in a transiting exoplanet system can impact its transit light curve, leading to sinusoidal transit-timing variations (TTV).
Zixin Zhang, Wenqin Wang, Xinyue Ma, Zhangliang Chen, Yonghao Wang, Cong Yu, Shangfei Liu, Yang Gao, Baitian Tang, Bo Ma   +9 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

TOI-4495: A Pair of Aligned, Near-resonant Sub-Neptunes That Likely Experienced Overstable Migration

The Astronomical Journal
We report the discovery of a sub-Neptune and a Neptune-like planet ( R ${}_{b}=2.4{8}_{-0.10}^{+0.14}$ R _⊕ , R ${}_{c}=4.0{3}_{-0.15}^{+0.23}$ R _⊕ ) orbiting the F-type star TOI-4495.
Mu-Tian Wang, Fei Dai, Hui-Gen Liu, Kento Masuda, Andrew W. Howard, Samuel Halverson, Howard Isaacson, Elina Y. Zhang, Max Goldberg, Huan-Yu Teng, Ryan A. Rubenzahl, Benjamin Fulton, Erik A. Petigura, Steven Giacalone, Luke Handley, David W. Latham, Allyson Bieryla, Ashley Baker, Jerry Edelstein, Steven R. Gibson, Kodi Rider, Arpita Roy, Chris Smith, Josh Walawender, David Rapetti, Jon M. Jenkins, Joshua N. Winn   +26 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Exoplanet Ephemerides Change Observations (ExoEcho). II. Transit Timing Variation Analysis of Brown Dwarfs around Solar-type Stars

The Astrophysical Journal
Transit timing variation (TTV) is a useful tool for studying the orbital properties of transiting objects. However, few TTV studies have been done on transiting brown dwarfs (BDs) around solar-type stars.
Wenqin Wang, Xinyue Ma, Zhangliang Chen, Cong Yu, Shangfei Liu, Bo Ma   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source