Results 51 to 60 of about 6,579 (217)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Inferring Exoplanet Parameters from Transit Timing Variations Using LSTM Networks
The Planetary Science JournalTransit timing variation (TTV) analysis provides a valuable complement to traditional transit and radial-velocity techniques, particularly in compact, near-resonant planetary systems where dynamical interactions amplify timing signals and refine mass and
Muhammad Isnaenda Ikhsan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
A Ground-based Transit Observation of the Long-period Extremely Low-density Planet HIP 41378 f
The Astronomical JournalWe present a ground-based transit detection of HIP 41378 f, a long-period ( P = 542 days), extremely low-density (0.09 ± 0.02 g cm ^−3 ) giant exoplanet in a dynamically complex system.
Juliana García-Mejía +27 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Updated Mass, Eccentricity, and Tidal Heating Constraints for the Earth-sized Planet LP 791-18 d
The Astronomical JournalLP 791-18 d is a temperate Earth-sized planet ( R _P = 1.03 R _⊕ , P = 2.76 days) orbiting a late M dwarf, with an interior super-Earth (LP 791-18 b, R _P = 1.2 R _⊕ , P = 0.95 days) and an exterior sub-Neptune (LP 791-18 c, R _P = 2.5 R _⊕ , P = 4.99 ...
Michael Greklek-McKeon +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A Planet Candidate Orbiting near the Hot Jupiter TOI-2818 b Inferred through Transit Timing
The Astrophysical JournalTOI-2818 b is a hot Jupiter orbiting a slightly evolved G-type star on a 4.04 day orbit that shows transit timing variations (TTVs) suggestive of a decreasing orbital period. In the most recent year of TESS observations, transits were observed ∼8 minutes
Brendan J. McKee +7 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Investigation of Transit Timing and an Optical Transmission Spectrum of the Hot Jupiter WASP-11 b
The Astronomical JournalWASP-11 b/HAT-P-10 b is an inflated hot Jupiter, which has a low density that makes it a good target for atmospheric studies using the transmission spectroscopy technique.
Napaporn A-thano +17 more
doaj +1 more source