Results 41 to 50 of about 6,579 (217)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
The Astronomical JournalThe ExoEcho project is designed to study the photodynamics of exoplanets by leveraging high-precision transit timing data from ground- and space-based telescopes.
Xinyue Ma +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Doomed Worlds. I. No New Evidence for Orbital Decay in a Long-term Survey of 43 Ultrahot Jupiters
The Planetary Science JournalUltrahot Jupiters (UHJs) are likely doomed by tidal forces to undergo orbital decay and eventual disruption by their stars, but the timescale over which this process unfolds is unknown. We present results from a long-term project to monitor UHJ transits.
Elisabeth R. Adams +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Accounting for Transit Timing Detectability: Biases in Planetary Radius and Orbital Period
The Astronomical JournalTransit Timing Variations (TTVs) are deviations from the time an observer would expect to see an exoplanet transit its host star. In multiplanetary systems, significant TTVs may indicate the presence of another body in the system gravitationally ...
Skylar D’Angiolillo +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A Decade of Transit-timing Measurements Confirm Resonance in the K2-19 System
The Astronomical JournalK2-19 is a star, slightly smaller than the Sun, that hosts three transiting planets. Two of these, K2-19 b and c, are between the size of Neptune and Saturn and have orbital periods near a 3:2 commensurability, and exhibit strong transit-timing ...
Paige M. Entrican +4 more
doaj +1 more source