Results 41 to 50 of about 6,653 (227)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

TOI-4504: Exceptionally Large Transit Timing Variations Induced by Two Resonant Warm Gas Giants in a Three-planet System

The Astrophysical Journal Letters
We present a joint analysis of transit timing variations (TTVs) and Doppler data for the transiting exoplanet system TOI-4504. TOI-4504 c is a warm Jupiter-mass planet that exhibits the largest known TTVs, with a peak-to-node amplitude of ∼2 days, the ...
Michaela Vítková, Rafael Brahm, Trifon Trifonov, Petr Kabáth, Andrés Jordán, Thomas Henning, Melissa J. Hobson, Jan Eberhardt, Marcelo Tala Pinto, Felipe I. Rojas, Nestor Espinoza, Martin Schlecker, Matías I. Jones, Maximiliano Moyano, Susana Eyheramendy, Carl Ziegler, Jack J. Lissauer, Andrew Vanderburg, Karen A. Collins, Bill Wohler, David Watanabe, George R. Ricker, Roland Vanderspek, Sara Seager, Joshua N. Winn, Jon M. Jenkins, Marek Skarka   +26 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Constraining the Presence of Companion Planets in Hot Jupiter Planetary Systems Using Transit-timing Variation Observations from TESS

The Astrophysical Journal Supplement Series
The presence of another planetary companion in a transiting exoplanet system can impact its transit light curve, leading to sinusoidal transit-timing variations (TTV).
Zixin Zhang, Wenqin Wang, Xinyue Ma, Zhangliang Chen, Yonghao Wang, Cong Yu, Shangfei Liu, Yang Gao, Baitian Tang, Bo Ma   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

TOI-4495: A Pair of Aligned, Near-resonant Sub-Neptunes That Likely Experienced Overstable Migration

The Astronomical Journal
We report the discovery of a sub-Neptune and a Neptune-like planet ( R ${}_{b}=2.4{8}_{-0.10}^{+0.14}$ R _⊕ , R ${}_{c}=4.0{3}_{-0.15}^{+0.23}$ R _⊕ ) orbiting the F-type star TOI-4495.
Mu-Tian Wang, Fei Dai, Hui-Gen Liu, Kento Masuda, Andrew W. Howard, Samuel Halverson, Howard Isaacson, Elina Y. Zhang, Max Goldberg, Huan-Yu Teng, Ryan A. Rubenzahl, Benjamin Fulton, Erik A. Petigura, Steven Giacalone, Luke Handley, David W. Latham, Allyson Bieryla, Ashley Baker, Jerry Edelstein, Steven R. Gibson, Kodi Rider, Arpita Roy, Chris Smith, Josh Walawender, David Rapetti, Jon M. Jenkins, Joshua N. Winn   +26 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Exoplanet Ephemerides Change Observations (ExoEcho). II. Transit Timing Variation Analysis of Brown Dwarfs around Solar-type Stars

The Astrophysical Journal
Transit timing variation (TTV) is a useful tool for studying the orbital properties of transiting objects. However, few TTV studies have been done on transiting brown dwarfs (BDs) around solar-type stars.
Wenqin Wang, Xinyue Ma, Zhangliang Chen, Cong Yu, Shangfei Liu, Bo Ma   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Transiting Giant on a 7.7 yr Orbit Revealed by Transit Timing Variations in the TOI-201 System

The Astrophysical Journal Letters
We report the detection and characterization of TOI-201 c, a long-period transiting companion to the warm Jupiter TOI-201 b. Its presence was first inferred from high-amplitude transit timing variations (TTVs) in TOI-201 b, pointing to a massive outer ...
Gracjan Maciejewski, Weronika Łoboda
doaj   +1 more source