Results 21 to 30 of about 6,579 (217)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Investigating Transit Timing Variations in the Ultrashort Period Exoplanet WASP-19b

The Astronomical Journal
In this study, we present a comprehensive analysis of transit timing variations (TTVs) in the ultrashort-period gas giant WASP-19b, which orbits a G-type main-sequence star.
Shraddha Biswas, Ing-Guey Jiang, Li-Chin Yeh, Hsin-Min Liu, Kaviya Parthasarathy, Devesh P. Sariya, D. Bisht, Mohit Singh Bisht, A. Raj   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Metrics for Optimizing Searches for Orbital Precession and Tidal Decay via Transit Timing and Occultation Timing

The Astronomical Journal
Short-period exoplanets may exhibit orbital precession driven by several different processes, including tidal interactions with their host stars and secular interactions with additional planets.
Brian Jackson, Elisabeth R. Adams, Rachel M. Huchmala, Malia Barker, Marvin Rothmeier, Jeffrey P. Morgenthaler, Amanda A. Sickafoose   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Warm Massive Pair of Planets around TOI-1232 Revealed with Transit-timing Variations and Doppler Spectroscopy

The Astronomical Journal
TOI-1232 is a G dwarf star with a mass of $1.0{6}_{-0.06}^{+0.07}\,{M}_{\odot }$ , a radius of 1.07 ± 0.05 R _⊙ , and a slightly higher metallicity than solar of Fe/H = 0.18 ± 0.05. The star hosts a transiting warm Jovian-mass planet, TOI-1232 b, with an
Deyan P. Mihaylov, Jan Eberhardt, Trifon Trifonov, Rafael Brahm, Thomas Henning, Andrés Jordán, Denitza Stoeva, Matías I. Jones, Lorena Acuña-Aguirre, Stefan Stefanov, M. Tala Pinto, Melissa J. Hobson, Nestor Espinoza, Felipe I. Rojas, Martin Schlecker, Vladimir Bozhilov, Tristan Guillot, Amaury H. M. J. Triaud, Jack J. Lissauer, Judith Korth, Hannu Parviainen, Laura Kreidberg, Philippe Bendjoya, Olga Suarez, Carl Ziegler, Pamela Rowden, Alexander Rudat, Veselin Kostov, Joshua N. Winn, Jon M. Jenkins, Karen A. Collins, Cristilyn N. Watkins, Don J. Radford, Chris Stockdale, Tianjun Gan   +34 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

TOI-4504: Exceptionally Large Transit Timing Variations Induced by Two Resonant Warm Gas Giants in a Three-planet System

The Astrophysical Journal Letters
We present a joint analysis of transit timing variations (TTVs) and Doppler data for the transiting exoplanet system TOI-4504. TOI-4504 c is a warm Jupiter-mass planet that exhibits the largest known TTVs, with a peak-to-node amplitude of ∼2 days, the ...
Michaela Vítková, Rafael Brahm, Trifon Trifonov, Petr Kabáth, Andrés Jordán, Thomas Henning, Melissa J. Hobson, Jan Eberhardt, Marcelo Tala Pinto, Felipe I. Rojas, Nestor Espinoza, Martin Schlecker, Matías I. Jones, Maximiliano Moyano, Susana Eyheramendy, Carl Ziegler, Jack J. Lissauer, Andrew Vanderburg, Karen A. Collins, Bill Wohler, David Watanabe, George R. Ricker, Roland Vanderspek, Sara Seager, Joshua N. Winn, Jon M. Jenkins, Marek Skarka   +26 more
doaj   +1 more source