Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
A Time-of-Flight Extraction Method Based on Time-Sequenced Pulses for Ultrasonic Flow Measurement Using an FPGA-Based Time-to-Digital Converter. [PDF]
Sensors (Basel)Fan E, Xie T, Wu F.
europepmc +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Urgent samples in clinical laboratories: stochastic batching to minimize patient turnaround time. [PDF]
Health Care Manag SciNovak A, Gnatowski A, Sucha P.
europepmc +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Structural physical activity restriction, cerebrovascular and diabetes mortality, and long-term care intensity in Japan: An ecological panel study across 47 prefectures (2013-2022) with a COVID-19 counterfactual analysis. [PDF]
Dialogues HealthKimura A.
europepmc +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
The Impact of Nasogastric Tubes (NGTs) on Swallow Function in Adults with Post-stroke Dysphagia: A Systematic Review. [PDF]
DysphagiaHanna L +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Overcoming the curse of knowledge: guidelines for reporting system-specific details of host infection and migration dynamics. [PDF]
Mov EcolBinning SA, Shaw AK.
europepmc +1 more source