Results 91 to 100 of about 1,076,752 (308)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
1996 summary : public transportation systems in Washington state [PDF]
The Washington State Department of Transportation (WSDOT) prepares the annual transit statistical summary. The intent for this summary, required by Section 35.58.2796 RCW, is to provide uniform data to transit providers, the Legislative Transportation ...
Washington (State). Public Transportation and Rail Division
core
Other title: Transportation fast facts 2012
, 2012 Previously published: Transportation fast facts 2008 / [prepared by the Connecticut Department of Transportation, in cooperation with the U.S. Department of Transportation, the Federal Highway Administration and the Federal Transit Administration ...
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cybersecurity Resilience Assessment Tool to Enhance Public Confidence in Transit [PDF]
I n 2021, the Federal Transit Administration (FTA) awarded the Rock Island County Metropolitan Mass Transit District (MetroLINK) a grant to develop a cybersecurity assessment tool to assess its cyber posture as part of FTA\u2019s Public Transportation ...
Thomas, Brandon +6 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Journal of Engineering and Applied ScienceThe straddle-type monorail system critically depends on the safe operation of pantographs, which are vulnerable to unstable contact, arc discharges, and structural impacts under complex conditions. To overcome the inefficiency of conventional maintenance
Wenjie Sun +4 more
doaj +1 more source
In vitro reconstitution of transition metal transporters
Journal of Biological ChemistryTransition metal ions are critically important across all kingdoms of life. The chemical properties of iron, copper, zinc, manganese, cobalt, and nickel make them very attractive for use as cofactors in metalloenzymes and/or metalloproteins. Their versatile chemistry in aqueous solution enables them to function both as electron donors and acceptors ...
Elvis L. Ongey, Anirban Banerjee
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Simulation of Transit Transportation along the Northern Sea Route under Climate Change. [PDF]
Stud Russ Econ Dev, 2021 Eliseev DO, Naumova YV.
europepmc +1 more source