Results 101 to 110 of about 1,076,752 (308)

A frequency-domain quantification of rotor harmonic and voltage fluctuation effects by electrical excitations

Discover Applied Sciences
This study investigates this electro-mechanical coupling by establishing a dynamic vehicle model that explicitly incorporates electric-induced traction forces. The model is used to analyze the system’s vibration response, with a focus on excitations from
Changxiu Yang, Yuxiao Li
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Influence of Urban Rail Transit Interchange Station Location on Passenger Interchange Route Selection

Chengshi guidao jiaotong yanjiu
Objective There are some non-quantifiable factors in the actual travel of passengers in urban rail transit (such as the position of interchange stations in the line network), which are challenging to quantify and convert into impedance in the multi-route
Li JIANG, Jiayao BAO, Ming GAO, Wei ZHU
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

e-Transit: Electronic Business Strategies for Public Transportation, Volume 4: Advanced Features of Transit Websites

, 2003
This volume, Volume 4 of TCRP Report 84, e-Transit: Electronic Business Strategies for Public Transportation, explores the potential of the following advanced website features for the transit industry: automated itinerary planners, real-time customer ...
Multisystems, Incorporated, Transportation Research Board   +1 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Transit and trail connections: assessment of visitor access to National Wildlife Refuges [PDF]

The purpose of the study is to characterize the use of transit and non-motorized transportation modes for visitor access to National Wildlife Refuges (NWRs), as well as identify opportunities for and constraints to alternative transportation access ...
John A. Volpe National Transportation Systems Center (U.S.)
core  

The efficiency forecast of trilateral transit transportation of economic corridor

Proceedings of the Mongolian Academy of Sciences, 2018
The development basis of a country is human capital which follows the transportation and infrastructure issues. In particular, landlocked countries with fewer neighbours ought to create transit transportations with its bordering countries that could help
Zolboo Gansukh
doaj   +1 more source