Results 161 to 170 of about 1,076,752 (308)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Transit in Washington, D.C.: Current Benefits and Optimal Level of Provision [PDF]
The discrepancy between transit’s large share of local transportation resources and its generally low share of local trips has raised questions about the use of scarce transportation funds for this purpose.
Harrington, Winston +4 more
core
Transitioning the Transport and Land-use system
, 2019 How can transport and land-use transitions in urban regions be understood and supported? This question is increasingly relevant for researchers and policy makers alike given the growing urgency of sustainability issues confronting cities and the limited improvements can be observed despite continued policy attention, for example Transit-oriented ...
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Coordination of transit concepts in GSMNP
DE-AC05-00OR22725The Great Smoky Mountains National Park, located along the border between North Carolina and Tennessee, is the most visited national park in the United States. This rugged, mountainous area presents many transportation challenges.
Chin, Shih-Miao +3 more
core
Workforce Development and Succession Planning to Prepare the Rural Transit Industry for the Future [PDF]
21177060-NCTR-NDSU07As America\u2019s transportation workforce continues to age, there is an increased need to invest in workforce development to combat the impending retirement tsunami.
University of South Florida. National Center for Transit Research (U.S.) +2 more
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Transportation Use, Trip Taking, and Trip Purposes Among Older Adults Not in the Labor Force: Evidence From the 2022 National Household Travel Survey. [PDF]
J Appl GerontolChoi NG, Marti CN.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source