Results 181 to 190 of about 1,076,752 (308)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The Transportation Needs of Seniors [PDF]

Over 208,000 residents of Hennepin County, Minnesota are over the age of 55, a number that is sure to rise. This paper examines the transportation needs of the elderly in Hennepin County through a mail out-mail back survey of their existing travel ...
Rania Wasfi, Ahmed El-Geneidy, David Levinson   +2 more
core  

Access to Essential Services: A Critical Factor for Predicting Recovery and Quantifying Resilience. [PDF]

Risk Anal
Swanson T, Guikema S, Nelson-Mercer B, Bricker J.   +3 more
europepmc   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Transit Benefits 2000 Working Papers: A Public Choice Policy Analysis [PDF]

FTA-TBP10The research presented here represents the Federal Transit Administration's (FTA) continuing effort to develop the professional literature on transportation benefits and their measurement.
United States. Department of Transportation. Federal Transit Administration
core  

Transportation-related factors, cancer screening, and stage at diagnosis: A scoping review. [PDF]

PLoS One
Pohl AL, Cohen-Tigör LA, Aderonmu AA, Doan A, Horton L, Ko B, Shideler B, Morris AM.   +7 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

New IDEAS for Transit: Transit IDEA Program Annual Report

, 2015
TRB’s Innovations Deserving Exploratory Analysis (IDEA) program has issued its New IDEAS for Transit: Transit IDEA Program Annual Report, which summarizes recent investigations conducted under the Transit IDEA program. The U.S.
Transportation Research Board, Transportation Research Board   +1 more
core  

Re-examining age-friendly communities for older people with insecure housing histories. [PDF]

Gerontologist
Weldrick R, Canham SL, Humphries J.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source