Results 1 to 10 of about 182,905 (303)

Inhibitory effects of knocking down homeobox C8 on seven factors-induced somatic cell reprogramming

浙江大学学报. 农业与生命科学版, 2022
To explore the mechanism of seven factors (Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Esrrb-Sall4)-induced somatic cell reprogramming, we analyzed the related role of homeobox C8 (Hoxc8) in the process of pluripotency network reconstruction through forward and reverse
HUANG Yi, FANG Shicai, WANG Bo, MING Jin, LI Chen, PEI Duanqing   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics

Developmental Cognitive Neuroscience
Thanks to methodological advances, large-scale data collections, and longitudinal designs, psychiatric neuroimaging is better equipped than ever to identify the neurobiological underpinnings of youth mental health problems.
Lorenza Dall’Aglio, Saúl Urbina Johanson, Travis Mallard, Sander Lamballais, Scott Delaney, Jordan W. Smoller, Ryan L. Muetzel, Henning Tiemeier   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Genetically Transitional Disease and the Road to Personalized Medicine

Genes
Genetically transitional disease (GTD) is emerging as a new concept in genomic medicine to straddle between the traditional binary classification of monogenic and polygenic disease. Genetic testing result reports in molecular laboratories have been predicated on the monogenic disease model, which focuses on pathogenic and likely pathogenic variants ...
Qingping Yao, Peter D. Gorevic, Greg Gibson   +2 more
openaire   +2 more sources

A Genetic Study on Lumbosacral Transitional Vertebra.

Orthopedics & Traumatology, 1991
Various studies have placed the prevalence of lumbosacral transitional vertebra to be anywhere from 0.6 to 25% of the general population.We found twenty cases of the transitional vertebra. They had a high frequency (64.2%) of the anomaly. There may be a genetic factor involved in the lumbosacral transitional vertebra.
Sonoda, Hideki, Hirano, Tetsuya, Takeuchi, Haruaki, Tomoda, Kunihiko, Yamashiro, Kenichi, Akasaki, Kouji, Kawaguchi, Eiji, Sakamoto, Kiminori, Matsueda, Yasuhiro   +8 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Anthocyanin contents and molecular changes in rose petals during the post-anthesis color transition

Ornamental Plant Research
Flower color transitions during anthesis are taxonomically widespread; however, the mechanisms underlying post-anthesis color transition in roses are unclear.
Ying Kong, Huan Wang, Li Qiu, Xiaoying Dou, Lixin Lang, Jinrong Bai   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source