Results 1 to 10 of about 480,286 (292)

The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning

Journal of Developmental Biology, 2018
EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to assume a precise array of three cell fates with high fidelity.
Hanna Shin, David J. Reiner
doaj   +1 more source

Application of the Moran Model in Estimating Selection Coefficient of Mutated CSF3R Clones in the Evolution of Severe Congenital Neutropenia to Myeloid Neoplasia

Frontiers in Physiology, 2020
Bone marrow failure (BMF) syndromes, such as severe congenital neutropenia (SCN) are leukemia predisposition syndromes. We focus here on the transition from SCN to pre-leukemic myelodysplastic syndrome (MDS).
Khanh N. Dinh, Seth J. Corey, Marek Kimmel, Marek Kimmel   +3 more
doaj   +1 more source

Phenotypic Plasticity Conferred by the Metastatic Microenvironment of the Brain Strengthens the Intracranial Tumorigenicity of Lung Tumor Cells

Frontiers in Oncology, 2021
Lung cancer is the leading cause of cancer-related deaths and is the primary source of brain metastases. Despite great advances in the study of the genetics and etiology of lung cancer in previous decades, the identification of the factors and mechanisms
Xu-Ge Wei, Ke-Wei Bi, Bo Li
doaj   +1 more source

The Spatiotemporal Control of Zygotic Genome Activation

iScience, 2019
Summary: One of the earliest and most significant events in embryonic development is zygotic genome activation (ZGA). In several species, bulk transcription begins at the midblastula transition (MBT) when, after a certain number of cleavages, the embryo ...
George E. Gentsch, Nick D.L. Owens, James C. Smith   +2 more
doaj   +1 more source

Inhibitory effects of knocking down homeobox C8 on seven factors-induced somatic cell reprogramming

浙江大学学报. 农业与生命科学版, 2022
To explore the mechanism of seven factors (Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Esrrb-Sall4)-induced somatic cell reprogramming, we analyzed the related role of homeobox C8 (Hoxc8) in the process of pluripotency network reconstruction through forward and reverse
HUANG Yi, FANG Shicai, WANG Bo, MING Jin, LI Chen, PEI Duanqing   +5 more
doaj   +1 more source

Reaction-diffusion equation for quark-hadron transition in heavy-ion collisions

, 2015
Reaction-diffusion equations with suitable boundary conditions have special propagating solutions which very closely resemble the moving interfaces in a first order transition.
Bagchi, Partha, Das, Arpan, Sengupta, Srikumar, Srivastava, Ajit M.   +3 more
core   +1 more source

Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae. [PDF]

, 2013
In the yeast Saccharomyces cerevisiae and most other eukaryotes, mitotic recombination is important for the repair of double-stranded DNA breaks (DSBs). Mitotic recombination between homologous chromosomes can result in loss of heterozygosity (LOH).
Petes, Thomas D, Yin, Yi
core   +1 more source

Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics

Developmental Cognitive Neuroscience
Thanks to methodological advances, large-scale data collections, and longitudinal designs, psychiatric neuroimaging is better equipped than ever to identify the neurobiological underpinnings of youth mental health problems.
Lorenza Dall’Aglio, Saúl Urbina Johanson, Travis Mallard, Sander Lamballais, Scott Delaney, Jordan W. Smoller, Ryan L. Muetzel, Henning Tiemeier   +7 more
doaj   +1 more source

Clonal interference and Muller's ratchet in spatial habitats

, 2014
Competition between independently arising beneficial mutations is enhanced in spatial populations due to the linear rather than exponential growth of clones.
Family F, Fisher R, Gillespie J H, Goldenfeld N, Gordo I, Gordo I, Henkel M, Jakub Otwinowski, Joachim Krug, Johnstone I M, Kimura M, Kolmogorov A N, Kriecherbauer T, Krug J, Kuhr J-T, Martens E A, Shaver A C, Tange O, Wright S   +18 more
core   +1 more source

Process Pathway Inference via Time Series Analysis [PDF]

, 2002
Motivated by recent experimental developments in functional genomics, we construct and test a numerical technique for inferring it process pathways, in which one process calls another process, from time series data. We validate using a case in which data
Nemenman, Ilya, Wiggins, Chris
core   +4 more sources