Results 131 to 140 of about 451,806 (340)

The asexual genome of Drosophila

, 2017
The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments ...
Lässig, Michael, Mustonen, Ville, Schiffels, Stephan   +2 more
core   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

The Spatiotemporal Control of Zygotic Genome Activation

iScience, 2019
Summary: One of the earliest and most significant events in embryonic development is zygotic genome activation (ZGA). In several species, bulk transcription begins at the midblastula transition (MBT) when, after a certain number of cleavages, the embryo ...
George E. Gentsch, Nick D.L. Owens, James C. Smith   +2 more
doaj  

The Research Space: using the career paths of scholars to predict the evolution of the research output of individuals, institutions, and nations

, 2016
In recent years scholars have built maps of science by connecting the academic fields that cite each other, are cited together, or that cite a similar literature.
Aristarán, Manuel, Guevara, Miguel R., Hartmann, Dominik, Hidalgo, César A., Mendoza, Marcelo   +4 more
core   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

The ongoing transition at an exponential speed from Conservation genetics to Conservation genomics [PDF]

, 2018
Pertoldi Cino, E. Randi
openalex   +3 more sources

Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics

Developmental Cognitive Neuroscience
Thanks to methodological advances, large-scale data collections, and longitudinal designs, psychiatric neuroimaging is better equipped than ever to identify the neurobiological underpinnings of youth mental health problems.
Lorenza Dall’Aglio, Saúl Urbina Johanson, Travis Mallard, Sander Lamballais, Scott Delaney, Jordan W. Smoller, Ryan L. Muetzel, Henning Tiemeier   +7 more
doaj  

MAMMALIAN POPULATION GENETICS: PROGRESS REPORT ON A WORLD VIEW IN TRANSITION [PDF]

, 1981
George F. Barrowclough
openalex   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Clonal interference and Muller's ratchet in spatial habitats

, 2014
Competition between independently arising beneficial mutations is enhanced in spatial populations due to the linear rather than exponential growth of clones.
Family F, Fisher R, Gillespie J H, Goldenfeld N, Gordo I, Gordo I, Henkel M, Jakub Otwinowski, Joachim Krug, Johnstone I M, Kimura M, Kolmogorov A N, Kriecherbauer T, Krug J, Kuhr J-T, Martens E A, Shaver A C, Tange O, Wright S   +18 more
core   +1 more source