Results 181 to 190 of about 480,980 (318)

Parkinson's disease in transition: Genetics, biomarkers, and emerging therapeutics

Sung‐Pin Fan, Ayami Okuzumi, Pin‐Shiuan Chen, Yi‐Cheng Tai, Yih‐Chih Kuo, Chun‐Hwei Tai, Cheng‐Hsuan Li, Han‐Lin Chiang, Taku Hatano, Chin‐Hsien Lin   +9 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Transition From Children's to Adults' Healthcare for Youth With (Genetic) Intellectual Disabilities: An ERN-ITHACA Guideline. [PDF]

J Intellect Disabil Res
Klein Haneveld MJ, Świeczkowska K, Grybek T, Labunets K, van Amelsvoort TAMJ, Bedeschi MF, Behan C, Dufke A, Dupont J, Gaasterland CMW, Garavelli L, Helverschou SB, McAnallen S, Milska-Musa KA, van Staa A, Streață I, Stumpel CTRM, Tamburrino F, Vasseghi M, Vyshka K, Wierzba JM, ERN‐ITHACA Guideline Working Group, van Eeghen AM.   +22 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Evaluating milk quality indicators in the era of antimicrobial stewardship: A study of tennessee dairy farms (2011-2023). [PDF]

PLoS One
Salvador RT, Vidlund J, Okafor CC.
europepmc   +1 more source

The ongoing transition at an exponential speed from Conservation genetics to Conservation genomics

, 2018
Cino Pertoldi, Ettore Randi
openalex   +2 more sources

Reassessing the mitochondrial DNA evidence for migration at the Mesolithic–Neolithic transition [PDF]

, 2008
Bonsall, Clive, Pickard, Benjamin, Pickard, Catriona   +2 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Editorial: The early detection of neurodegenerative diseases: an aging perspective. [PDF]

Front Aging Neurosci
Abondio P, Masi M, Wang S.
europepmc   +1 more source