Results 191 to 200 of about 480,980 (318)

Calculation of the transition density of allele frequencies in probabilistic models in population genetics

, 2013
Julia Theresa Csar
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Feasibility of transition research in pituitary disease using patient registries: a EuRREB secondary survey. [PDF]

Endocr Connect
Shishkov S, Iotova V, Pelsma I, Priego Zurita AL, Biermasz N, Endo-ERN Pituitary Transition of Care Study Group, Ahmed F.   +6 more
europepmc   +1 more source

Continuous and Discontinuous Phase Transitions in Quantitative Genetics: the role of stabilizing selective pressure [PDF]

, 2014
Annalisa Fierro, Sergio Cocozza, Antonella Monticelli, Giovanni Scala, Gennaro Miele, Monte S. Angelo, Cnr Napoli   +6 more
openalex  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The MIR157-SPL15 module regulates flowering and inflorescence development in Arabidopsis thaliana under short days and in Arabis alpina. [PDF]

PLoS Genet
Roggen A, Lloret A, Miotto Y, Wang K, Luxa K, Oruganti V, Della Pina S, van Driel AD, Hyun Y, Huettel B, Coupland G.   +10 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Bibliometric Analysis of Global Research on Cafe-Au-Lait Macules from 2000 to 2025: Development, Collaboration Patterns, and Emerging Trends. [PDF]

Clin Cosmet Investig Dermatol
Li Y, Liu Y, Gao F, Jiang F.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment and maintenance of NRT2.1 inter-individual variability in plants. [PDF]

PLoS Genet
Lecuyer C, Vettor A, Fizames C, Javot H, Martin A, Mazouzi M, Montané MH, Cortijo S.   +7 more
europepmc   +1 more source