Results 51 to 60 of about 451,806 (340)
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Stochastic slowdown in evolutionary processes
, 2010 We examine birth--death processes with state dependent transition probabilities and at least one absorbing boundary. In evolution, this describes selection acting on two different types in a finite population where reproductive events occur successively.
Arne Traulsen +14 more
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning
Journal of Developmental Biology, 2018 EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to assume a precise array of three cell fates with high fidelity.
Hanna Shin, David J. Reiner
doaj +1 more source
The Genetics of Fitness Reorganization During the Transition to Multicellularity: The Volvocine regA-Like Family as a Model [PDF]
, 2023 Zachariah I. Grochau-Wright +2 more
openalex +2 more sources
Mutation in Populations Governed by a Galton-Watson Branching Process
, 2018 A population genetics model based on a multitype branching process, or equivalently a Galton-Watson branching process for multiple alleles, is pre- sented. The diffusion limit forward Kolmogorov equation is derived for the case of neutral mutations.
Burden, Conrad J., Wei, Yi
core +1 more source
Fixation of a Deleterious Allele under Mutation Pressure and Finite Selection Intensity [PDF]
, 2011 The mean fixation time of a deleterious mutant allele is studied beyond the diffusion approximation. As in Kimura's classical work [M. Kimura, Proc. Natl. Acad. Sci. U.S.A.
Assaf +41 more
core +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
From rat pathophysiology to genomic medicine: an interview with Howard Jacob
Disease Models & Mechanisms, 2016 Howard Jacob is best known for pioneering genomic sequencing of a patient to solve a mysterious pediatric case in 2010. With roots in pharmacology and cardiovascular disease, however, his career has largely been dedicated to dissecting the physiology and
doaj +1 more source
Agronomy, 2023 Bacterial leaf blight (BLB) is a devastating disease caused by Xanthomonas oryzae pv. oryzae (Xoo), which poses a significant threat to global rice production.
Chananton Danaisilichaichon +6 more
doaj +1 more source