Results 71 to 80 of about 480,286 (292)

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Genome-Wide Association Study Using Genotyping by Sequencing for Bacterial Leaf Blight Resistance Loci in Local Thai Indica Rice

Agronomy, 2023
Bacterial leaf blight (BLB) is a devastating disease caused by Xanthomonas oryzae pv. oryzae (Xoo), which poses a significant threat to global rice production.
Chananton Danaisilichaichon, Phanchita Vejchasarn, Sujin Patarapuwadol, Alessandro Tondelli, Giampiero Valè, Theerayut Toojinda, Chatchawan Jantasuriyarat   +6 more
doaj   +1 more source

Error threshold in the evolution of diploid organisms

, 1996
The effects of error propagation in the reproduction of diploid organisms are studied within the populational genetics framework of the quasispecies model. The dependence of the error threshold on the dominance parameter is fully investigated.
D Alves, Eigen M, Eigen M, Eigen M, Franz S, Galluccio S, Hartl D L, J F Fontanari, Kauffman S A, Leuthäusser I   +9 more
core   +1 more source

A Genetic Study on Lumbosacral Transitional Vertebra.

Orthopedics & Traumatology, 1991
Various studies have placed the prevalence of lumbosacral transitional vertebra to be anywhere from 0.6 to 25% of the general population.We found twenty cases of the transitional vertebra. They had a high frequency (64.2%) of the anomaly. There may be a genetic factor involved in the lumbosacral transitional vertebra.
Hideki Sonoda, Tetsuya Hirano, Haruaki Takeuchi, Kunihiko Tomoda, Kenichi Yamashiro, Kouji Akasaki, Eiji Kawaguchi, Kiminori Sakamoto, Yasuhiro Matsueda   +8 more
openaire   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Anthocyanin contents and molecular changes in rose petals during the post-anthesis color transition

Ornamental Plant Research
Flower color transitions during anthesis are taxonomically widespread; however, the mechanisms underlying post-anthesis color transition in roses are unclear.
Ying Kong, Huan Wang, Li Qiu, Xiaoying Dou, Lixin Lang, Jinrong Bai   +5 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Fluctuation Domains in Adaptive Evolution

, 2010
We derive an expression for the variation between parallel trajectories in phenotypic evolution, extending the well known result that predicts the mean evolutionary path in adaptive dynamics or quantitative genetics.
Abrams, Carl Boettiger, Champagnat, Champagnat, Champagnat, Chevin, Cooper, Dieckmann, Dieckmann, Duffy, Feller, Gentleman, Geritz, Geritz, Geritz, Geritz, Gillespie, Hofbauer, Jonathan Dushoff, Joshua S. Weitz, Kimura, Kimura, Kurtz, Lande, Lande, Levins, Levins, Nowak, Ohta, Olsen, Rueffler, Schwab, Stodden, van Kampen, Wichman, Wright, Wright   +36 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reduction of a metapopulation genetic model to an effective one island model [PDF]

, 2018
We explore a model of metapopulation genetics which is based on a more ecologically motivated approach than is frequently used in population genetics. The size of the population is regulated by competition between individuals, rather than by artificially
Alan J. McKane, Crow J. F., César Parra-Rojas, Gardiner C. W., Hanski I., Pielou E. C., van Kampen N. G., Wiggins S., Wright S.   +8 more
core   +2 more sources