Results 71 to 80 of about 182,905 (303)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Diffusion processes and coalescent trees [PDF]

, 2009
We dedicate this paper to Sir John Kingman on his 70th Birthday. In modern mathematical population genetics the ancestral history of a population of genes back in time is described by John Kingman’s coalescent tree.
R. C. Griffiths, Spanò, Dario, Spano, D, Griffiths, R. C., Griffiths, Robert C., D. Spanó, Griffiths, Robert, Griffiths, RC   +7 more
core   +1 more source

Glycerol phenylbutyrate efficacy and safety from an open label study in pediatric patients under 2 months of age with urea cycle disorders

, 2021
Background/aims: Neonatal onset Urea cycle disorders (UCDs) can be life threatening with severe hyperammonemia and poor neurological outcomes. Glycerol phenylbutyrate (GPB) is safe and effective in reducing ammonia levels in patients with UCD above 2 ...
Hainline, Bryan, Vescio, Thomas, Ah Mew, Nicholas, Kok, Teresa, Porter, Marty H., Conway, Robert L., Bannick, Allison A., Diaz, George A., Canavan, Colleen, Inbar-Feigenberg, Michal, Berry, Susan A., McCandless, Shawn E., Longo, Nicola, Zori, Roberto, Lichter-Konecki, Uta, Schulze, Andreas   +15 more
core   +1 more source

The Spatiotemporal Control of Zygotic Genome Activation

iScience, 2019
Summary: One of the earliest and most significant events in embryonic development is zygotic genome activation (ZGA). In several species, bulk transcription begins at the midblastula transition (MBT) when, after a certain number of cleavages, the embryo ...
George E. Gentsch, Nick D.L. Owens, James C. Smith   +2 more
doaj   +1 more source

A Fleming-Viot process and Bayesian nonparametrics [PDF]

, 2007
This paper provides a construction of a Fleming-Viot measure valued diffusion process, for which the transition function is known, by extending recent ideas of the Gibbs sampler based Markov processes.
Nicoleris, Theodoros, Hatjispyros, Spyridon J., Walker, Stephen G.   +2 more
core   +1 more source

Recent and Ancient Signature of Balancing Selection around the S-Locus in Arabidopsis halleri and A. lyrata [PDF]

, 2013
Balancing selection can maintain different alleles over long evolutionary times. Beyond this direct effect on the molecular targets of selection, balancing selection is also expected to increase neutral polymorphism in linked genome regions, in inverse ...
Ruggiero, Maria-Valeria, Roux, Camille, Pauwels, M., Roux, Clément, Castric, Vincent, Vekemans, X., Pauwels, Maxime, M.-V., Ruggiero, Charlesworth, D., Vekemans, Xavier, Charlesworth, Deborah   +10 more
core   +1 more source

Analysis of diversity-dependent species evolution using concepts in population genetics

, 2021
In this work, we consider a two-type species model with trait-dependent speciation, extinction and transition rates under an evolutionary time scale. The scaling approach and the diffusion approximation techniques which are widely used in mathematical ...
Kaj, Ingemar,, Lascoux, Martin,, Kaj, Ingemar, Glémin, Sylvain, Tahir, Daniah, Lascoux, Martin, Tahir, Daniah,, Glémin, Sylvain,   +7 more
core   +1 more source

The rise of behavioral genetics and the transition to behavioral genomics and beyond

, 2017
Krüger O, Korsten P, Hoffman J. The rise of behavioral genetics and the transition to behavioral genomics and beyond. In: Call J, ed. APA handbook of comparative psychology: Basic concepts, methods, neural substrate, and behavior, Vol. 1.
Hoffman, Joseph ; https://orcid.org/, Call, Josep, Korsten, Peter ; https://orcid.org/, Krüger, Oliver   +3 more
core   +1 more source

Transition to chaos in models of genetic networks [PDF]

, 2008
Randomly constructed networks of N elements governed by piecewise linear differential equations have been proposed as models for neural and genetic networks. In this model an element is labelled “on” if it is above a threshold, and “off” otherwise.
C. Hill, B. Sawhill, S. Kauffman, L. Glass   +3 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source