Results 91 to 100 of about 182,905 (303)

A Flaming-Viot Process and Bayesian non Parametric [PDF]

This paper provides a construction of a Fleming-Viot measure valued diffusion process, for which the transition function is known, by extending recent ideas of Gibbs sampler based Markov processes.
Theodoros Nicoleris, Spyridon J. Hatjispyros, Stephen G. Walker   +2 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Clinical molecular genetics in the UK c.1975-c.2000

, 2014
seminar transcriptChaired by Professor Martin Bobrow and introduced by Professor Bob Williamson, this Witness Seminar included geneticists from a broad range of research and clinical specialities.
Jones, EM, Tansey, EM
core  

A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-Phase entry in Drosophila

, 2004
Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1- to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which ...
Amin, Nancy, Brumby, Anthony, Horsfield, J., Amin, N., Coates, D., Richardson, H., Horsfield, Julie A, Secombe, Julie, Saint, Robert, Saint, R., Coombe, Michelle, Coombe, M., Brumby, A., Secombe, J., Richardson, Helena, Coates, Deborah   +15 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Transition-transversion bias is not universal: A counter example from grasshopper pseudogenes

, 2007
(c) 2007 Keller et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Richard A. Nichols, Bensasson Douda, Bensasson, D, Nichols Richard A, Irene Keller, Keller Irene, Nichols, RA., Richard A Nichols, Keller, I, Douda Bensasson, Nichols, RA   +10 more
core   +1 more source

The Genetics of Obesity in Transition

Collegium antropologicum, 2013
Recent advances in human genetics have revealed a number of genes influencing the susceptibility to obesity and related conditions, but it is likely that their contribution to disease is contingent on numerous environmental factors. As the obesity epidemic has occurred over a relatively short period of recent history, use of gene-by-year of birth ...
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The neutral population model and Bayesian non-parametrics [PDF]

, 2008
Fleming-Viot processes are a wide class of probability-measure-valued diffusions which often arise as large population limits of so-called particle processes.
Walker, S. G. (Stephen G.), Favaro, Stefano, Ruggiero, Matteo, Spanò, Dario   +3 more
core  

Stochastic hypothesis of transition from inborn neutropenia to AML: Interactions of cell population dynamics and population genetics

Frontiers in Oncology, 2013
We present a stochastic model of driver mutations in the transition from severe congenital neutropenia to myelodysplastic syndrome to acute myeloid leukemia (AML). The model has the form of a multitype branching process.
Marek eKimmel, Seth eCorey
doaj   +1 more source