Results 81 to 90 of about 480,286 (292)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Theranostics: A treasured tailor for tomorrow
Journal of Pharmacy and Bioallied Sciences, 2014 Emerging as a targeted, safe, and efficient pharmacotherapy is the approach of theranostics, which focuses on patient-centered care. It is a combination of diagnosis and therapeutics.
S Jeelani +5 more
doaj +1 more source
IT Complexity Revolution: Intelligent Tools for the Globalised World Development
, 2009 Globalised-civilisation interaction intensity grows exponentially, involving all dimensions and regions of planetary environment. The resulting dynamics of critically high, exploding complexity urgently needs consistent understanding and efficient ...
Kirilyuk, Andrei, Ulieru, Mihaela
core +4 more sources
Statistical Physics of Evolutionary Trajectories on Fitness Landscapes [PDF]
, 2013 Random walks on multidimensional nonlinear landscapes are of interest in many areas of science and engineering. In particular, properties of adaptive trajectories on fitness landscapes determine population fates and thus play a central role in ...
Manhart, Michael, Morozov, Alexandre V.
core +1 more source
Transition to chaos in models of genetic networks [PDF]
, 2008 Randomly constructed networks of N elements governed by piecewise linear differential equations have been proposed as models for neural and genetic networks. In this model an element is labelled “on” if it is above a threshold, and “off” otherwise.
C. Hill +3 more
openaire +1 more source
Identifying genetic networks underlying myometrial transition to labor [PDF]
Genome Biology, 2005 Abstract Background Early transition to labor remains a major cause of infant mortality, yet the causes are largely unknown. Although several marker genes have been identified, little is known about the underlying global gene expression patterns and pathways that orchestrate these striking changes.
Salomonis, Nathan +7 more
openaire +4 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The asexual genome of Drosophila
, 2017 The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments ...
Lässig, Michael +2 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Error-prone polymerase activity causes multinucleotide mutations in humans
, 2014 About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single generation. MNMs have the potential to accelerate the pace at which single genes
Harris, Kelley, Nielsen, Rasmus
core +3 more sources