Results 21 to 30 of about 561,665 (262)

pygtm : a python Geospatial Transition Matrix toolbox

open access: yes, 2021
The Geospatial Transition Matrix toolbox allows the creation of a transition matrix, representing a Markov Chain of the dynamics, from a set of trajectories.
Luzie Helfmann, Philippe Miron
core   +1 more source

Calculation of LTC Premiums based on direct estimates of transition probabilities [PDF]

open access: yes, 2004
In this paper we model the life-history of LTC patients using a Markovian multi-state model in order to calculate premiums for a given LTC-plan. Instead of estimating the transition intensities in this model we use the approach suggested by Andersen et ...
Helms, F.   +3 more
core   +1 more source

Simultaneous Improvement in Strength and Ductility of TC4 Matrix Composites Reinforced with Ti1400 Alloy and In Situ-Synthesized TiC

open access: yes, 2023
To overcome the tradeoff between strength and ductility of materials and obtain titanium matrix composites with excellent mechanical properties, in this study, the in situ-synthesized TiC particles and Ti-Al-V-Mo-Cr (Ti1400) alloy-reinforced Ti6Al4V (TC4)
Mingjia Li   +6 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Multicritical matrix models and the chiral phase transition

open access: yes, 1998
Universality of multicritical unitary matrix models is shown and a new scaling behavior is found in the microscopic region of the spectrum, which may be relevant for the low energy spectrum of the Dirac operator at the chiral phase ...
Akemann, G, Akemann, Gernot, G. Akemann
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Average transition matrix.

open access: yes, 2018
Transition matrix (a) for normal cases (b) for abnormal cases (c) average transition matrix TMavg (d) net transition matrix TMnet (e) binary neighborhood matrix NM (e) conditioned net transition matrix TMc.
Jayanthi Sivaswamy (5983034)   +2 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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