Results 81 to 90 of about 561,665 (262)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Land use transition matrix between 1990-2010(%).
, 2018 Land use transition matrix between 1990-2010(%).
Dongcai Shu (4903630) +4 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Empirical Transition Matrix of Multi-State Models: The etm Package
Multi-State models provide a relevant framework for modelling complex event histories. Quantities of interest are the transition probabilities that can be estimated by the empirical transition matrix, that is also referred to as the Aalen-Johansen ...
Martin Schumacher +2 more
core
Simulating Phase Equilibria using Wang-Landau-Transition Matrix Monte Carlo
, 2014 We will examine the strengths and weaknesses of the Wang-Landau and transition matrix Monte Carlo methods for simulating phase equilibria of continuous molecular systems alone and as a combined Wang-Landautransition matrix Monte Carlo algorithm. Although
McCabe, Clare; id_orcid +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Transition matrix for the Markov chain model.
, 2019 Each entry in the matrix is the probability of a transition between disease states.
Michael W. Dzierlenga (2193622) +4 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Transition matrix network structure.
, 2015 Example structure of the transition matrix with 100 nodes, NL = 20, and NC = 3 visualized as a network. The darkness of edges is proportional to the probability of a transition along that edge. Even though there are more between-cluster links than within-
Matthieu Laneuville (815548) +3 more
core +1 more source