Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Consistent and Non-Degenerate Model Specification Tests Against Smooth Transition Alternatives [PDF]
In this paper we develop a test of functional form that is consistent against any deviation from the null specification, and directs power towards a class of nonlinear "smooth transition" functional forms.
Jonathan B. Hill
core
The Trust-Link Relational Transition Model: A Unitary Caring Framework for Youth With HIV Transitioning to Adult Healthcare. [PDF]
J Adv NursBarr EA, Horton-Deutsch S.
europepmc +1 more source
Dolutegravir-Based Regimen Ensures High Virological Success despite Prior Exposure to Efavirenz-Based First-LINE ART in Cameroon: An Evidence of a Successful Transition Model. [PDF]
Viruses, 2022 Semengue ENJ +28 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A multiple regime smooth transition heterogeneous autoregressive model for long memory and asymmetries [PDF]
In this paper we propose a flexible model to capture nonlinearities and long-range dependence in time series dynamics. The new model is a multiple regime smooth transition extension of the Heterogenous Autoregressive (HAR) model, which is specifically ...
Marcelo C. Medeiros, Michael McAller
core
Protein intake and transitions between frailty states in middle-aged and older adults: a multi-state transition model in the UK Biobank. [PDF]
BMC MedMendonça N +5 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Identifying Important Factors for Depressive Symptom Dynamics in Chinese Middle-Aged and Older Adults Using a Multi-State Transition Model with Feature Selection. [PDF]
Behav Sci (Basel)Ma C, Lu T, Li Y, Chen S.
europepmc +1 more source
Cutting Force Transition Model Considering the Influence of Tool System by Using Standard Test Table. [PDF]
Sensors (Basel), 2021 Chen X, Zhang D, Wang Q.
europepmc +1 more source