Results 191 to 200 of about 1,438,980 (312)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Is postoperative cognitive dysfunction a disease of microglial inflammatory memory? A state-transition model from metabolic stress to epigenetic lock-in. [PDF]

Front Mol Neurosci
Wu X, He T, He F, Liu L.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Results of a multicenter, randomized trial examining a new transition model for post-kidney transplant adolescents. [PDF]

Sci Rep
Kreuzer M, Prüfe J, Dierks ML, Müther S, Bethe D, Büscher A, Heindl-Rusai K, Hollenbach S, Hoppe B, John-Kroegel U, Kanzelmeyer NK, Klaus G, Kranz B, Oh J, Pohl M, Rieger S, Ruckenbrodt B, Sauerstein K, Staude H, Taylan C, Thumfart J, Weitz M, Ringlstetter R, Großhennig A, Pape L.   +24 more
europepmc   +1 more source

A BEHAVIORALLY-INTEGRATED INDIVIDUAL-LEVEL STATE-TRANSITION MODEL THAT CAN PREDICT RAPID CHANGES IN EVACUATION DEMAND DAYS EARLIER. [PDF]

Transp Res E Logist Transp Rev, 2021
Guan X, Chen C.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Female Employment and Timing of Births Decisions: A Multiple State Transition Model

In this paper we estimate a multiple state transition model, describing transitions into maternity and labor market transitions for women.Each state is characterized by two components: the labor market state and the maternity state.
Bloemen, H.G., Kalwij, A.S.
core  

Modelling the Effect of Viruses on Insect Survival: Using a Second-Order Phase Transition Model to Describe Time-Effect and Dose-Effect Relationships Using Entomopathogenic Viruses as an Example. [PDF]

Insects
Soukhovolsky V, Kovalev A, Tarasova O, Kurenshchikov D, Tokarev Y, Kharlamova D, Akhanaev Y, Pavlushin S, Martemyanov V.   +8 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Constructing a doxycycline-inducible system for an epithelial-to-mesenchymal transition model in MCF10A cells. [PDF]

Biol Open
Sun Y, Zhou X, Hu X.
europepmc   +1 more source