Results 231 to 240 of about 4,558,660 (292)
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
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FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Modeling rating transitions [PDF]
Journal of the Korean Statistical Society, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Weißbach, Rafael, Mollenhauer, Thomas
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Seminars in Pediatric Neurology, 2020
Without a structure to address healthcare transition, adolescents and young adults with neurological disorders are likely to have disruptions in their care that result in a higher need for emergency care and hospitalization. There are numerous obstacles to implementing the existing transition guidelines: adequate numbers of skilled and willing adult ...
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Without a structure to address healthcare transition, adolescents and young adults with neurological disorders are likely to have disruptions in their care that result in a higher need for emergency care and hospitalization. There are numerous obstacles to implementing the existing transition guidelines: adequate numbers of skilled and willing adult ...
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Psychological Reports, 1992
A comprehensive model of divorce experience can provide a useful framework for organizing available information, for incorporating research results, and for planning therapeutic interventions with divorcing clients. The concept that the experience of divorce can be thought of as a cluster of specific small divorces is combined with transition theory ...
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A comprehensive model of divorce experience can provide a useful framework for organizing available information, for incorporating research results, and for planning therapeutic interventions with divorcing clients. The concept that the experience of divorce can be thought of as a cluster of specific small divorces is combined with transition theory ...
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2002
Abstract This chapter considers extensions of generalized linear models (GLMs) for describing the conditional distribution of each response yij as an explicit function of past responses yij’1,..., yi1 and covariates xij.
Peter J Diggle +3 more
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Abstract This chapter considers extensions of generalized linear models (GLMs) for describing the conditional distribution of each response yij as an explicit function of past responses yij’1,..., yi1 and covariates xij.
Peter J Diggle +3 more
openaire +1 more source
Modeling Electrified Transit Systems
IEEE Transactions on Vehicular Technology, 2010This paper introduces a new modeling method for light rail traction to allow a detailed drive model to be incorporated into the tram system, thereby permitting detailed energy flows to be studied. Using movement data as an input, this method is shown to be highly suitable for cases employing real measured telemetry to compare the efficiencies of light ...
Chymera, Martyn Z. +3 more
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