Results 61 to 70 of about 292,642 (264)

Computation of the Likelihood of Joint Site Frequency Spectra Using Orthogonal Polynomials

open access: yesComputation, 2016
In population genetics, information about evolutionary forces, e.g., mutation, selection and genetic drift, is often inferred from DNA sequence information.
Claus Vogl, Juraj Bergman
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Poisson Spaces with a Transition Probability [PDF]

open access: yesReviews in Mathematical Physics, 1997
The common structure of the space of pure states ℘ of a classical or a quantum mechanical system is that of a Poisson space with a transition probability. This is a topological space equipped with a Poisson structure, as well as with a function p:℘×℘→[0,1], with certain properties.
openaire   +3 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Magnetic Multipole Transition Probabilities [PDF]

open access: yesHighlights of Astronomy, 1971
AbstractA review is given of the occurrence and transition probabilities of spectrum lines arising from magnetic quadrupole radiation. Magnetic dipole radiation in relativistic quantum mechanics is also discussed.
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Disparity in Performance of the Czech Construction Sector: Evidence from the Markov‑Switching Model

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2018
Activities in the construction sector are assumed to be influenced by inflow of mortgage funding in the private housing sector and public finances targeted at large infrastructure projects, apart from climate variables. In this study, we modeled seasonal
Václav Adamec
doaj   +1 more source

UNIFORM TIGHTNESS FOR TRANSITION PROBABILITIES

open access: yesTamkang Journal of Mathematics, 1995
The aim of this paper is to give a notion of uniform tightness for transition probabilities on topological spaces, which assures the uniform tightness of compound probability measures. Then the upper semicontinuity of set-valued mappings are used in essence.
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

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