Results 81 to 90 of about 1,476,337 (273)

Neural Correlate of Transition Violation and Deviance Detection in the Songbird Auditory Forebrain

open access: yesFrontiers in Systems Neuroscience, 2018
Deviants are stimuli that violate one's prediction about the incoming stimuli. Studying deviance detection helps us understand how nervous system learns temporal patterns between stimuli and forms prediction about the future. Detecting deviant stimuli is
Mingwen Dong, David S. Vicario
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Computation of the Likelihood of Joint Site Frequency Spectra Using Orthogonal Polynomials

open access: yesComputation, 2016
In population genetics, information about evolutionary forces, e.g., mutation, selection and genetic drift, is often inferred from DNA sequence information.
Claus Vogl, Juraj Bergman
doaj   +1 more source

Dissipative Landau-Zener transitions of a qubit: bath-specific and universal behavior

open access: yes, 2007
We study Landau-Zener transitions in a qubit coupled to a bath at zero temperature. A general formula is derived that is applicable to models with a non-degenerate ground state.
E. C. G. Stueckelberg   +14 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Error-driven Global Transition in a Competitive Population on a Network

open access: yes, 2004
We show, both analytically and numerically, that erroneous data transmission generates a global transition within a competitive population playing the Minority Game on a network.
Choe, Sehyo Charley   +2 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Building a multistate model from electronic health records data for modeling long-term diabetes complications

open access: yesJournal of Clinical and Translational Science
Objective: The progression of long-term diabetes complications has led to a decreased quality of life. Our objective was to evaluate the adverse outcomes associated with diabetes based on a patient’s clinical profile by utilizing a multistate modeling ...
Riza C. Li   +4 more
doaj   +1 more source

Disparity in Performance of the Czech Construction Sector: Evidence from the Markov‑Switching Model

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2018
Activities in the construction sector are assumed to be influenced by inflow of mortgage funding in the private housing sector and public finances targeted at large infrastructure projects, apart from climate variables. In this study, we modeled seasonal
Václav Adamec
doaj   +1 more source

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