Results 91 to 100 of about 1,054,375 (301)

Crosstalk between autophagy and bladder transitional cell carcinoma by autophagy-related lncRNAs. [PDF]

Medicine (Baltimore), 2023
Feng J, Wang M, Du GS, Peng K, Li LQ, Li XS.   +5 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Concurrent Xanthogranulomatous Pyelonephritis and Upper Urinary Tract Transitional Cell Carcinoma. [PDF]

Case Rep Urol, 2023
Guglin A, Weiss R, Singh A, Mittal A, Hwang T, Shah A.   +5 more
europepmc   +1 more source

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Ureteral transitional cell carcinoma with supraclavicular lymph node metastasis: a case report. [PDF]

J Surg Case Rep, 2023
Gupta A, Mirpuri L, Hassan H, Malik F, Amtul N.   +4 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

A Retrospective Clinico-Pathologic Study of 35 Dogs with Urethral Transitional Cell Carcinoma Undergoing Treatment. [PDF]

Animals (Basel), 2023
Ghisoni G, Foglia A, Sabattini S, Agnoli C, Dondi F, Perfetti S, Marconato L.   +6 more
europepmc   +1 more source

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Nature Genetics, 2011
Yaoting Gui, Guangwu Guo, Yi Huang, Xueda Hu, A. Tang, Shengjie Gao, R. Wu, Chao Chen, Xianxin Li, Liang Zhou, M. He, Zesong Li, Xiaojuan Sun, Wenlong Jia, Jinnong Chen, Shangming Yang, F. Zhou, Xiaokun Zhao, Shengqing Wan, R. Ye, C. Liang, Zhi-Su Liu, Peide Huang, Chunxiao Liu, Hui Jiang, Yong Wang, Hancheng Zheng, Liang Sun, Xingwang Liu, Zhi-mao Jiang, Dafei Feng, Jing Chen, Song Wu, Jing Zou, Zhongfu Zhang, Ruilin Yang, Jun Zhao, Congjie Xu, W. Yin, Zhichen Guan, Jiongxian Ye, Hong Zhang, Jingxiang Li, K. Kristiansen, M. Nickerson, D. Theodorescu, Yingrui Li, Xiuqing Zhang, Songgang Li, Jian Wang, Huanming Yang, J. Wang, Z. Cai   +52 more
semanticscholar   +1 more source

PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reveals that PDZK1 loss impairs ULK1‐mediated lipophagy, driving lipid droplet accumulation and sunitinib resistance in clear cell renal cell carcinoma. PDZK1 inhibits LEF1 nuclear translocation, enhancing ULK1 transcription. Pharmacological ULK1 activation resensitizes resistant tumors to sunitinib.
Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He   +11 more
wiley   +1 more source