Results 141 to 150 of about 17,923 (299)
Study on the Nonlinear Vibration Characteristic of Bending-torsional Coupled Single-stage Gear
Jixie chuandong, 2019 Taking spur gear pair as the research object, a 6-DOF coupled bending-torsion nonlinear vibration model including time-varying meshing stiffness, comprehensive error, backlash and input torque is established. Based on the bifurcation diagram and Poincare
Rongju Liu +3 more
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Overcoming machine learning training data imbalance by simulating exoplanet transits [PDF]
We propose to use simulations of exoplanet transits to improve training outcomes for Machine Learning models. Machine learning has huge potential in exoplanet detection but faces challenges due to data imbalance and lack of ground truth in observational ...
Creaner, Oisin, Gorchakova, Nika
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Monitoring and analyzing exoplanetary transits from Argentina
, 2017 Photometric observations of transits can be used to derive physical and orbital parameters of the system, like the planetary and stellar radius, orbital inclination and mean density of the star.
Miguel, Yamila +3 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source