Results 41 to 50 of about 9,880 (233)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Validating the Orbital Periods of the Coolest TESS Planet Candidates

The Astronomical Journal
When an exoplanet passes in front of its host star, the resulting eclipse causes an observable decrease in stellar flux, and when multiple such transits are detected, the orbital period of the exoplanet can be determined. Over the past seven years NASA’s
Dillon J. Bass, Daniel C. Fabrycky
doaj   +1 more source

Review of the AC Overhead Wires, the DC Third Rail and the DC Fourth Rail Transit Lines: Issues and Challenges

IEEE Access, 2020
This paper focuses on transits available around the world. AC voltage transits and DC voltage transit are reviewed and compared. Emphasis is given to differences, advantages and disadvantages of voltage supplies and traction types.
Farah Asyikin Abd Rahman, Mohd Zainal Abidin Ab Kadir, Miszaina Osman, Ungku Anisa Ungku Amirulddin   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Single Transit Detection in Kepler with Machine Learning and Onboard Spacecraft Diagnostics

The Astronomical Journal
Exoplanet discovery at long orbital periods requires reliably detecting individual transits without additional information about the system. Common techniques, like phase folding of light curves and periodogram analysis of radial velocity data, are more ...
Matthew T. Hansen, Jason A. Dittmann
doaj   +1 more source

Observations of planetary transits at the University Observatory Jena

EPJ Web of Conferences, 2011
We report on observations of transit events of the transiting planets XO-1b, TrES-1 and TrES-2 with a 25 cm telescope of the University Observatory Jena.
Rammo W., Reithe A., Tetzlaff N., Moualla M., Marka C., Ginski Ch., Hohle M.M., Koeltzsch A., Vaňko M., Eisenbeiss T., Roell T., Schmidt T.O.B., Mugrauer M., Raetz S., Fiedler S., Koppenhoefer J., Neuhäuser R.   +16 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source