Results 61 to 70 of about 140,835 (316)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Proxima Centauri b is not a transiting exoplanet

, 2019
We report Spitzer Space Telescope observations during predicted transits of the exoplanet Proxima Centauri b. As the nearest terrestrial habitable-zone planet we will ever discover, any potential transit of Proxima b would place strong constraints on its
Amado, Pedro J., Anglada-Escudé, Guillem, Butler, R. Paul, Challener, Ryan C., Dreizler, Stefan, Harrington, Joseph, Himes, Michael D., Jenkins, James S., Kempton, Eliza M. -R., Kipping, David, Kurtovic, Nicolás T., McIntyre, Kathleen J., Murgas, Felipe, Ofir, Aviv, Palle, Enric, Peña, Jose, Ramirez, Ricardo, Ribas, Ignasi, Rodríguez, Eloy, Rodríguez-López, Cristina, Rojas, Pablo A. Peña, Rojo, Patricio   +21 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Transit Photometry as an Exoplanet Discovery Method

, 2018
Photometry with the transit method has arguably been the most successful exoplanet discovery method to date. A short overview about the rise of that method to its present status is given.
A Collier Cameron, A Collier Cameron, A Giménez, A Léger, A Santerne, A Shporer, A Udalski, AMS Smith, Andrew Collier Cameron, B Tingley, BE McArthur, C Elachi, C Moutou, C Régulo, CA Haswell, D Bayliss, D Charbonneau, D Charbonneau, D Koch, D Queloz, D. J. Christian, DL Pollacco, DM Kipping, DW Latham, DW Latham, F Bouchy, F Pont, FT O’Donovan, G Kovács, G Kovács, G Torres, G Torres, G Torres, GR Ricker, GW Henry, GÁ Bakos, H Rauer, H. Parviainen, HJ Deeg, HJ Deeg, HJ Deeg, HJ Deeg, IAG Snellen, J Scalo, J. Cabrera, JA Dittmann, Jason F. Rowe, Jeffrey L. Coughlin, JJ Lissauer, JJ Lissauer, JJ Lissauer, JM Almenara, JM Jenkins, JM Jenkins, JM Jenkins, JN Winn, JT Wright, K Horne, K Mandel, KC Sahu, LR Doyle, M Gillon, M Konacki, MN Günther, MN Günther, NM Batalha, O Struve, O Tamuz, P Barge, PJ Wheatley, PJ Wheatley, R Alonso, R Alonso, R Alonso, RF Díaz, RL Gilliland, RL Gilliland, S Aigrain, S Aigrain, S Jha, S Seager, SB Howell, Smith AMS WASP Consortium, TD Morton, TD Morton, TG Beatty, TM Brown, WJ Borucki, ZK Berta   +88 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Five Kepler target stars that show multiple transiting exoplanet candidates [PDF]

, 2010
We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates.
Adams, Althea V. Moorhead, Batalha, Beatty, Borucki, Charbonneau, Claret, Daniel C. Fabrycky, Darin Ragozzine, David Koch, David W. Latham, Dimitar D. Sasselov, Douglas A. Caldwell, Eric B. Ford, Fabrycky, Ford, Fortney, François Fressin, Geoffrey Marcy, Gillon, Grasset, Guillermo Torres, Hartman, Howard Isaacson, Jack J. Lissauer, Jason F. Rowe, Jason H. Steffen, Jon M. Jenkins, Jonathan J. Fortney, Jurić, Koch, Koch, Lars A. Buchhave, Lee, Lee, Mandel, Marcus, Marcus, Matthew J. Holman, Meschiari, Michael Endl, Michael J. Haas, Natalie M. Batalha, Nesvorný, O'Donovan, Phillip J. MacQueen, Pilecki, Press, Prsa, Ragozzine, Robert C. Morehead, Rogers, Samuel N. Quinn, Sara Seager, Seager, Steffen, Steffen, Steve B. Howell, Torres, Valencia, William D. Cochran, William F. Welsh, William J. Borucki, Wright, Wu, Yee, Zakamska   +66 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Additional JWST/NIRSpec Transits of the Rocky M Dwarf Exoplanet GJ 1132 b Reveal a Featureless Spectrum

The Astronomical Journal
As an archetypal M-dwarf rocky exoplanet, GJ 1132 b has a varied history of atmospheric measurements. At 1.13 R _⊕ , 1.66 M _⊕ , and 580 K, it orbits a bright, slowly rotating M dwarf in a 1.6 day period, making it a prime target for characterization. In
Katherine A. Bennett, Ryan J. MacDonald, Sarah Peacock, Junellie Perez, E. M. May, Sarah E. Moran, Lili Alderson, Jacob Lustig-Yaeger, Hannah R. Wakeford, David K. Sing, Kevin B. Stevenson, Natasha E. Batalha, Mercedes López-Morales, Munazza K. Alam, Joshua D. Lothringer, Guangwei Fu, James Kirk, Jeff A. Valenti, L. C. Mayorga, Kristin S. Sotzen   +19 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Constraints on Evolutionary Timescales for M Dwarf Planets from Dynamical Stability Arguments

The Astrophysical Journal, 2023
The diversity of dynamical conditions among exoplanets is now well established. Yet, the relevance of orbital dynamical timescales to biological evolutionary timescales is poorly understood.
Katie Teixeira, Sarah Ballard
doaj   +1 more source