Results 81 to 90 of about 17,923 (299)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Transits in poorly sampled data - Gaia and beyond

, 2008
Gaia, an ESA cornerstone mission, will obtain of the order of 100 high-precision photometric observations over five years for tens of millions of stars with V < 17. The vast number of red dwarfs in this data set, with their correspondingly deep (high S/N)
Tingley, Brandon, Brandon Tingley
core   +1 more source

Spitzer Transits of the Super-Earth GJ1214b and Implications for Its Atmosphere [PDF]

, 2012
peer reviewedWe observed the transiting super-Earth exoplanet GJ1214b using Warm Spitzer at 4.5 microns wavelength during a 20-day quasi-continuous sequence in May 2011.
Lewis, Nikole, Sara Seager, Deming, Drake, Jonathan D. Fraine, Jehin, Emmanuel, Gillon, M., Demory, Brice-Olivier, Benneke, Bjoern, Knutson, Heather A., Fraine, Jonathan D., Gillon, Michaël, Bjoern Benneke, Knutson, Heather, Lewis, Nikole K., Desert, Jean-Michel, Drake Deming, Seager, Sara, Nikole K. Lewis, Brice-olivier Demory, Heather Knutson   +19 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Origins of Super Jupiters: TOI-2145b has a Moderately Eccentric and Nearly Aligned Orbit

The Astronomical Journal
Super Jupiters are giant planets with several Jupiter masses. It remains an open question whether these planets originate with such high masses or grow through collisions.
Jiayin Dong, Ashley Chontos, George Zhou, Gudmundur Stefansson, Songhu Wang, Chelsea X. Huang, Arvind F. Gupta, Samuel Halverson, Shubham Kanodia, Jacob K. Luhn, Suvrath Mahadevan, Andrew Monson, Jaime A. Alvarado-Montes, Joe P. Ninan, Paul Robertson, Arpita Roy, Christian Schwab, Jason T. Wright   +17 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Hundreds of TESS Exoplanets Might Be Larger than We Thought

The Astrophysical Journal Letters
The radius of a planet is a fundamental parameter that probes its composition and habitability. Precise radius measurements are typically derived from the fraction of starlight blocked when a planet transits its host star.
Te Han, Paul Robertson, Timothy D. Brandt, Shubham Kanodia, Caleb Cañas, Avi Shporer, George Ricker, Corey Beard   +7 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Bering Strait and Arctic Transits [PDF]

This report provides a summary of AIS equipped vessel transits in 2024 and makes comparisons to data gathered over the past ...

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