Results 71 to 80 of about 394,172 (251)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Gastric emptying of a glucose drink is predictive of the glycaemic response to oral glucose and mixed meals, but unrelated to antecedent glycaemic control, in type 2 diabetes

Nutrition & Diabetes
Background Gastric emptying (GE), with wide inter-individual but lesser intra-individual variations, is a major determinant of postprandial glycaemia in health and type 2 diabetes (T2D).
Chunjie Xiang, Yixuan Sun, Yong Luo, Cong Xie, Weikun Huang, Zilin Sun, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Jianhua Ma, Tongzhi Wu   +10 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

AHRC Translating Cultures Workshop, Thursday 27 June 2013

, 2013
AHRC Translating Cultures Workshop Concepts, Theories, Methods Date: Thursday 27 June 2013 Time: 11am-5pm Venue: Room 349, Institute of Germanic and Romance Studies, School of Advanced Study, University of London, Senate House, Malet Street, London, WC1E
Charles Forsdick
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Translating Cultures: French Caribbean History, Literature and Migration

, 2018
Translating Cultures: French Caribbean History, Literature and Migration Monday 24 September 2018, 10.15 -17:00, British Library Knowledge Centre A study day organised in partnership with the AHRC ‘Translating Cultures’ theme, the Eccles Centre for ...
Charles Forsdick
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Call for Papers: Translating the Literatures of Small European Nations

, 2014
Call for Papers: Translating the Literatures of Small European Nations International Conference, University of Bristol, September 8th-10th 2015 Conference Organisers: Dr Rajendra Chitnis (Bristol), Dr Rhian Atkin (Cardiff), Professor Zoran Milutinovic ...
Charles Forsdick
core   +1 more source

From momentarity to perfective multiplicity. Different aspects of the aorist

Cognitive Studies | Études cognitives, 2015
From momentarity to perfective multiplicity. Different aspects of the aorist The aim of this work is a analysis of temporal meanings, and aspectual research.
Joanna Satoła-Staśkowiak
doaj   +1 more source