Results 171 to 180 of about 1,773,214 (315)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding. [PDF]

PLoS Comput Biol
Liu Y, Reisbitzer A, Dorešić D, Hasenauer J, Krauß S, Tchumatchenko T.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Improving survival in childhood acute lymphoblastic leukemia (ISCALL): An adaptive mixed-method hub-spoke model of implementation of the ICiCLe standard of care across India

Pediatric Hematology Oncology Journal
Shreya Ghosh, Sameer Bakhshi, Rachna Seth, Amita Trehan, Nirmalya Roy Moulik, Pritam Singha Roy, Smita Kayal, T. Priyakumari, Anand Prakash, Akash Kumar, Sumita Chaudhry, Narendra Kumar Chaudhary, Shilpa Khanna Arora, Nidhi Chopra, Piali Mandal, Siyaram Didel, Prashant Chhabra, Vyas Rathaur, Alka Yadav, Sanjeev Digra, Vishvdeep Khushoo, Raghwesh Ranjan, Velagala Swetha Venkatareddy, Aditi Lingayat, Sonali Mohapatra, Munlima Hazarika, Rachana Chennamaneni, Stuti Bhargava, Nandana Das, Venkatraman Radhakrishnan   +29 more
doaj   +1 more source

Exploring the effects of task complexity and translation anxiety on EFL learners' translation performance: Evidence from a mixed-design study. [PDF]

PLoS One
Zhou X, Liu X.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Quantitative magnetic resonance imaging during knee hyperextension for the evaluation of screw-home mechanism abnormalities in patients with anterior cruciate ligament injury: a clinical study. [PDF]

Quant Imaging Med Surg
Li Z, Chen W, Chen J, Tan X, Li S.
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Reader reception of translation strategies for Li Bai's "Yu Jie Yuan": Empirical evidence from a mixed-methods study. [PDF]

PLoS One
Chang H, Zhao J, Sun Y, Ding H.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source