Results 41 to 50 of about 1,357,475 (274)

Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study

Critical Care, 2020
Background Clinical frailty among older adults admitted to intensive care has been proposed as an important determinant of patient outcomes. Among this group of patients, an acute episode of delirium is also common, but its relationship to frailty and ...
David Sanchez, Kathleen Brennan, Masar Al Sayfe, Sharon-Ann Shunker, Tony Bogdanoski, Sonja Hedges, Yu Chin Hou, Joan Lynch, Leanne Hunt, Evan Alexandrou, Manoj Saxena, Simon Abel, Ramanathan Lakshmanan, Deepak Bhonagiri, Michael J. Parr, Anders Aneman, Danielle Ni Chroinin, Kenneth M. Hillman, Steven A. Frost   +18 more
doaj   +1 more source

Rethinking Round-Trip Translation for Machine Translation Evaluation [PDF]

arXiv, 2022
Automatic evaluation on low-resource language translation suffers from a deficiency of parallel corpora. Round-trip translation could be served as a clever and straightforward technique to alleviate the requirement of the parallel evaluation corpus. However, there was an observation of obscure correlations between the evaluation scores by forward and ...
arxiv  

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Current landscape of mRNA technologies and delivery systems for new modality therapeutics

Journal of Biomedical Science
Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects.
Ruei-Min Lu, Hsiang-En Hsu, Ser John Lynon P. Perez, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Yin-Shiou Lin, Ching-Hang Liu, Shih-Han Ko, Christian Angelo P. Concio, Yi-Jen Su, Yi-Han Chang, Wen-Shan Li, Han-Chung Wu   +13 more
doaj   +1 more source

Optimizing Machine Translation through Prompt Engineering: An Investigation into ChatGPT's Customizability [PDF]

Proceedings of Machine Translation Summit XIX, Vol. 2: Users Track, pages 195-204, September 4-8, 2023, Macau SAR, China, 2023
This paper explores the influence of integrating the purpose of the translation and the target audience into prompts on the quality of translations produced by ChatGPT. Drawing on previous translation studies, industry practices, and ISO standards, the research underscores the significance of the pre-production phase in the translation process.
arxiv  

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Quick Back-Translation for Unsupervised Machine Translation [PDF]

arXiv, 2023
The field of unsupervised machine translation has seen significant advancement from the marriage of the Transformer and the back-translation algorithm. The Transformer is a powerful generative model, and back-translation leverages Transformer's high-quality translations for iterative self-improvement.
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Evaluative reports on medical malpractice policies in obstetrics: a rapid scoping review

Systematic Reviews, 2017
Background The clinical specialty of obstetrics is under particular scrutiny with increasing litigation costs and unnecessary tests and procedures done in attempts to prevent litigation.
Roberta Cardoso, Wasifa Zarin, Vera Nincic, Sarah Louise Barber, Ahmet Metin Gulmezoglu, Charlotte Wilson, Katherine Wilson, Heather McDonald, Meghan Kenny, Rachel Warren, Sharon E. Straus, Andrea C. Tricco   +11 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source