Results 61 to 70 of about 1,226,445 (266)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Delivering the National Diabetes Prevention Program: Assessment of Retention, Physical Activity, and Weight Loss Outcomes by Participant Characteristics and Delivery Modes

Journal of Diabetes Research
Type 2 diabetes disproportionately affects older adults, persons from racial and ethnic minority groups, and persons of low socioeconomic status. It can be prevented or delayed through evidence-based interventions such as the National Diabetes Prevention
Boon Peng Ng, Elizabeth Ely, Michelle Papali’i, Michael J. Cannon   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Barriers to preventive care among US adults of multiple races eligible for type 2 diabetes screening: an observational study

BMC Public Health
Background Little is known about disparities in access to preventive care among people of multiple races, who are often aggregated into a single category, despite comprising a heterogeneous population. We therefore described the prevalence of barriers to
Alain K. Koyama, Stephen Onufrak, Kai McKeever Bullard, Fang Xu, Michelle Papali’i, Yoshihisa Miyamoto, Ryan Saelee, Meda E. Pavkov   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The effectiveness of guideline implementation strategies in the dental setting: a systematic review

Implementation Science, 2019
Background Guideline implementation has been an ongoing challenge in the dental practice setting. Despite this, there are no reviews summarising the existing evidence regarding effective guideline implementation strategies in this setting.
Amy R. Villarosa, Della Maneze, Lucie M. Ramjan, Ravi Srinivas, Michelle Camilleri, Ajesh George   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

ChatGPT translation vs. human translation: an examination of a literary text

Cogent Social Sciences
This study evaluates the proficiency of ChatGPT-based translation compared to Human Translation (HT) using an Arabic literary work. It also examines potential translation gaps in ChatGPT and explores its potential to replace human translators.
Rafat Al Rousan, Raghad Jaradat, Mona Malkawi   +2 more
doaj   +1 more source

A Study on the Influence of Local Top Leaders' Corruption——An Empirical Analysis Based on the Municipal Party Committee Secretaries Sacked after the Eighteenth National Congress of the Communist Party of China

Contemporary Social Sciences, 2017
Based on the cross-sectional data about the municipal Party committee secretaries sacked since the 18th CPC National Congress, this paper adopts a regression model to examine and assess the impact of local top Party leaders’ corruption.
Liao Chongxu, Li Huoqiang, Zhou Dong
doaj   +1 more source