Results 71 to 80 of about 5,276,450 (332)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Statistically motivated example-based machine translation using translation memory [PDF]
, 2010 In this paper we present a novel way of integrating Translation Memory into an Example-based Machine translation System (EBMT) to deal with the issue of low resources. We have used a dialogue of 380 sentences as the example-base for our system.
Dandapat, Sandipan +3 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Projection of the future diabetes burden in the United States through 2060
Population Health Metrics, 2018 Background In the United States, diabetes has increased rapidly, exceeding prior predictions. Projections of the future diabetes burden need to reflect changes in incidence, mortality, and demographics.
Ji Lin +6 more
doaj +1 more source
BMC Geriatrics, 2020 Background Prescribing trends suggest that pharmacologic alternatives to antipsychotics are gaining in popularity, but randomized trial (RCT) data of their comparative safety is scarce.
Jennifer A. Watt +10 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
Journal of Biomedical ScienceRealizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects.
Ruei-Min Lu +13 more
doaj +1 more source
Limitless translation limits translation [PDF]
Nature, 2017 Evidence has now been found that ribosomes — the cell’s translational apparatus — can pass beyond the main protein-coding region of messenger RNAs to form ‘traffic jams’ that inhibit protein expression. Evidence has now been found that ribosomes — the cell’s translational apparatus — can pass beyond the main protein-coding region of messenger RNAs to ...
openaire +2 more sources
Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation
Nature Cell Biology, 2018 N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate.
Huilin Huang +29 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source