Results 91 to 100 of about 1,226,445 (266)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Patients’ experiences while undergoing high-intensity gait training during inpatient stroke rehabilitation: a qualitative study

BMC Health Services Research
Background High-intensity gait training is an evidence-based intervention for improving walking outcomes after stroke, but little is known about how patients experience this intervention during inpatient rehabilitation. Understanding patient perspectives
Jennifer L. Moore, Julia A. Mbalilaki, Stein A. Rimehaug, Siri N. Tveitan, Anne-Margrethe Linnestad, Pia Krøll, Simen Lundberg, Marianne Molle, Ingvild Lilleheie   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Investigating the impact of lexical simplicity and sophistication on stylistic rendering in English–Arabic translation

Cogent Arts & Humanities
This study investigates the effects of lexical simplicity and sophistication on stylistic choices in English-to-Arabic translation, and examines how task conditions and student performance influence those choices.
Israa Alquda, Dina Mahmoud Hammouri, Ahmad S. Haider, Eman Alshammari, Hadeel Saed, Sausan Abu Tair, Noor Darwish   +6 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Decoy Nanoparticles and Protein Corona Modulation: A Novel Frontier in Sepsis Treatment

International Journal of Nanomedicine
Evgeniya R Denisova,1 Darya S Volkova,1 Valeria V Streltsova,1 Stepan A Kopytov,1 Artem S Krivosheev,1 Elizaveta V Panfilova,1 Neng Yan,2 Dmitry Kostyushev,3– 6 Mazdak Ganjalikhani-Hakemi,7 Vadim S Pokrovsky,8,9 Manu Lopus,10 Andrey V Golovin,1,6 Andrey ...
Denisova ER, Volkova DS, Streltsova VV, Kopytov SA, Krivosheev AS, Panfilova EV, Yan N, Kostyushev D, Ganjalikhani-Hakemi M, Pokrovsky VS, Lopus M, Golovin AV, Zamyatnin Jr AA, Celia C, Parodi A   +14 more
doaj  

The translatics of translation

Journal of Modern Languages, 2017
The project on which this paper is based offers Translatics as a theory of translation which is designed and developed as an alternative that challenges the mainstream views currently held within translation studies. To familiarize the readers with Translatics, an attempt will be made to provide and describe its foundational key concepts and features ...
openaire   +8 more sources