Results 111 to 120 of about 1,294,309 (219)

Improving survival in childhood acute lymphoblastic leukemia (ISCALL): An adaptive mixed-method hub-spoke model of implementation of the ICiCLe standard of care across India

Pediatric Hematology Oncology Journal
Shreya Ghosh, Sameer Bakhshi, Rachna Seth, Amita Trehan, Nirmalya Roy Moulik, Pritam Singha Roy, Smita Kayal, T. Priyakumari, Anand Prakash, Akash Kumar, Sumita Chaudhry, Narendra Kumar Chaudhary, Shilpa Khanna Arora, Nidhi Chopra, Piali Mandal, Siyaram Didel, Prashant Chhabra, Vyas Rathaur, Alka Yadav, Sanjeev Digra, Vishvdeep Khushoo, Raghwesh Ranjan, Velagala Swetha Venkatareddy, Aditi Lingayat, Sonali Mohapatra, Munlima Hazarika, Rachana Chennamaneni, Stuti Bhargava, Nandana Das, Venkatraman Radhakrishnan   +29 more
doaj   +1 more source

From preclinical promise to regulatory reality: translation of small rodent acute injury therapies to human approval and safety outcomes: A systematic review. [PDF]

PLoS One
Entwistle TR, Cowey WR, Stokoe E, Stone JP, Fildes JE.   +4 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Persistence-confidence incongruence and engagement in translation learning: a response surface analysis. [PDF]

Front Psychol
Chen C, Guo Z.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Novel Lateral Tibiofibular Index for Simulated Posterior Fibular Translation: A Three-Dimensional CT Study. [PDF]

J Clin Med
Tanoğlu O, Kahraman HÇ.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Concept-aware contrastive representation learning for cross-translation semantic consistency modeling of the Analects. [PDF]

PLoS One
He T, Dai P, Wang R, Zhao Y, Zhao C.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Relationship between anterior ankle laxity and anterior talar translation during landing using dual fluoroscopic imaging. [PDF]

Front Bioeng Biotechnol
Luo Y, Li F, Huang X, Xiao Q, Feng L, Li L, Luo Y, Wang S.   +7 more
europepmc   +1 more source