Results 121 to 130 of about 1,226,445 (266)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Unlocking translational resilience for mRNA vaccines by viral UTRs. [PDF]

Mol Ther Nucleic Acids
Minnell JJ, Vink JNA, McKenzie RE.
europepmc   +1 more source

TRANSLATOR’S NOTE -Translators and Translating

Translation Today, 2007
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Exploring translator's style in children's literature: A case study of Nicky Harman's English translations of Huang Beijia's two works. [PDF]

PLoS One
He H, Wang H.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Improving survival in childhood acute lymphoblastic leukemia (ISCALL): An adaptive mixed-method hub-spoke model of implementation of the ICiCLe standard of care across India

Pediatric Hematology Oncology Journal
Shreya Ghosh, Sameer Bakhshi, Rachna Seth, Amita Trehan, Nirmalya Roy Moulik, Pritam Singha Roy, Smita Kayal, T. Priyakumari, Anand Prakash, Akash Kumar, Sumita Chaudhry, Narendra Kumar Chaudhary, Shilpa Khanna Arora, Nidhi Chopra, Piali Mandal, Siyaram Didel, Prashant Chhabra, Vyas Rathaur, Alka Yadav, Sanjeev Digra, Vishvdeep Khushoo, Raghwesh Ranjan, Velagala Swetha Venkatareddy, Aditi Lingayat, Sonali Mohapatra, Munlima Hazarika, Rachana Chennamaneni, Stuti Bhargava, Nandana Das, Venkatraman Radhakrishnan   +29 more
doaj   +1 more source

Folding the message: mRNA structure as a regulatory layer of human mitochondrial gene expression. [PDF]

Biochim Biophys Acta Mol Cell Res
Ahn A, Hong S, Brischigliaro M, Fontanesi F, Barrientos A.   +4 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Reading to Translate or Translating to Read? Modeling Translators' Eye Movements with Multilingual Pre-Trained Models. [PDF]

J Eye Mov Res
Zhang Y, Yao X, Li D.
europepmc   +1 more source