Results 101 to 110 of about 1,773,214 (315)

A Study on the Influence of Local Top Leaders' Corruption——An Empirical Analysis Based on the Municipal Party Committee Secretaries Sacked after the Eighteenth National Congress of the Communist Party of China

open access: yesContemporary Social Sciences, 2017
Based on the cross-sectional data about the municipal Party committee secretaries sacked since the 18th CPC National Congress, this paper adopts a regression model to examine and assess the impact of local top Party leaders’ corruption.
Liao Chongxu, Li Huoqiang, Zhou Dong
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Translation as human-computer interaction [PDF]

open access: yes, 2012
This paper seeks to characterise translation as a form of human-computer interaction. The evolution of translator-computer interaction is explored and the challenges and benefits are enunciated.
O'Brien, Sharon, O\u27Brien, Sharon
core   +1 more source

ChatGPT translation vs. human translation: an examination of a literary text

open access: yesCogent Social Sciences
This study evaluates the proficiency of ChatGPT-based translation compared to Human Translation (HT) using an Arabic literary work. It also examines potential translation gaps in ChatGPT and explores its potential to replace human translators.
Rafat Al Rousan   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Literary translation as a three-stage process : machine translation, post-editing and revision

open access: yes, 2022
This study focuses on English-Dutch literary translations that were created in a professional environment using an MT-enhanced workflow consisting of a three-stage process of automatic translation followed by post-editing and (mainly) monolingual ...
Vanroy, BramUGent0001615296528020026585439747705382060000-0002-4622-8364C50B0474-7EE0-11E7-B38D-2BA4AD28A064   +19 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Statistically motivated example-based machine translation using translation memory [PDF]

open access: yes, 2010
In this paper we present a novel way of integrating Translation Memory into an Example-based Machine translation System (EBMT) to deal with the issue of low resources. We have used a dialogue of 380 sentences as the example-base for our system.
Morrissey, Sara   +3 more
core  

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