Results 131 to 140 of about 7,340,134 (257)

Community translation

, 2022
Community translation facilitates communication between national and local public services, on the one hand, and speakers of non-official or minority languages on the other.
Taibi, Mustapha (R12032)
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Targeting Translation Activity at the Ribosome Interface with UV-Active Small Molecules. [PDF]

ACS Omega, 2019
Kandala DT, Del Piano A, Minati L, Clamer M.   +3 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Regulation of the translation activity of antigen-specific mRNA is responsible for antigen loss and tumor immune escape in a HER2-expressing tumor model. [PDF]

Sci Rep, 2019
Han BS, Ji S, Woo S, Lee JH, Sin JI.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Harmonizing measurement tools: examining the concurrent validity of the Daily Activity Behaviors Questionnaire compared to the ActiGraph to assess 24-hour movement behaviors among adults

BMC Public Health
Purpose An accurate assessment of time spent in 24-hour movement behaviors (24 h-MBs) is crucial in exploring health related associations. This study aims to evaluate the concurrent validity of the Daily Activity Behavior Questionnaire (DABQ) compared to
Iris Willems, Vera Verbestel, Dorothea Dumuid, Patrick Calders, Bruno Lapauw, Marieke De Craemer   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Protein Translation Activity: A New Measure of Host Immune Cell Activation. [PDF]

J Immunol, 2016
Seedhom MO, Hickman HD, Wei J, David A, Yewdell JW, Yewdell JW.   +5 more
europepmc   +1 more source

A concept mapping approach to explore the perceived facilitating factors in shifting sedentary behavior into (more) physical activity: perspectives of healthcare professionals versus sedentary and/or inactive adults

BMC Public Health
Purpose Healthcare professionals (HCPs) such as Physical Activity on Prescription (PAP)-coaches and physiotherapists might play a crucial role in activating sedentary and/or inactive adults, which in turn might benefit their health.
Iris Willems, Vera Verbestel, Teatske Altenburg, Dorothea Dumuid, Patrick Calders, Marieke De Craemer   +5 more
doaj   +1 more source