Results 101 to 110 of about 3,070,291 (402)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH

Nature Communications
Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress, where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome.
Niraj Kumar, Shivani Sharma, Prem S. Kaushal   +2 more
doaj   +1 more source

Maximizing Protein Translation Rate in the Ribosome Flow Model: the Homogeneous Case [PDF]

, 2014
Gene translation is the process in which intracellular macro-molecules, called ribosomes, decode genetic information in the mRNA chain into the corresponding proteins. Gene translation includes several steps.
Margaliot, Michael, Tuller, Tamir, Zarai, Yoram   +2 more
core  

Introduction to Translation. [PDF]

, 2013
We introduce here the inaugural issue of the new scientific journal Translation. The overarching aim of this endeavor is to establish a new forum for a broad spectrum of research in the area of protein synthesis in living systems ranging from structural ...
Hershey, John WB, Polunovsky, Vitaly A, Sonenberg, Nahum   +2 more
core   +1 more source

The spatial biology of transcription and translation in rapidly growing Escherichia coli

Frontiers in Microbiology, 2015
Single-molecule fluorescence provides high resolution spatial distributions of ribosomes and RNA polymerase (RNAP) in live, rapidly growing Escherichia coli.
Somenath Bakshi, Heejun Choi, J. Weisshaar   +2 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Circadian biology in translation

The FASEB Journal, 2019
The past several decades has seen an explosion of growth in mechanistic understanding of circadian clocks in several model organisms, including humans. However, translation of that knowledge into actionable medical intervention(s) has been slow to non‐existent. Here, I will discuss some of the reasons why this is as well as our efforts to mitigate this
openaire   +1 more source

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

Nature Biotechnology, 2018
The ability to predict the impact of cis-regulatory sequences on gene expression would facilitate discovery in fundamental and applied biology. Here we combine polysome profiling of a library of 280,000 randomized 5′ untranslated regions (UTRs) with deep
Paul J. Sample, Ban Wang, David W. Reid, Vladimir Presnyak, I. McFadyen, D. Morris, Georg Seelig   +6 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Journal of Hematology & Oncology, 2020
Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the
Win Topatana, Sarun Juengpanich, Shijie Li, Jiasheng Cao, Jiahao Hu, Jiyoung Lee, Kenneth Suliyanto, D. Ma, Bin Zhang, Mingyu Chen, Xiujun Cai   +10 more
semanticscholar   +1 more source